341 results
Primary objective: Our primary objective is to investigate whether niagen normalizes blood-based energy metabolites, mitochondrial levels and proteostasis levels. Secondary objective: To examine whether niagen reduces AF burden in patients with…
To test the hypothesis that patients with AoS have a higher prevalence of CHIP driving mutations compared to control subjects. Secondary objectives are to perform extensive phenotyping of circulating monocytes.
Main objectiveTo identify and describe the electrophysiological substrate and triggers in patients with (an increased risk of) VTAs using ECGI, in order to improve understanding of arrhythmic mechanisms and use these for arrhythmia risk…
Primary: to investigate the effectiveness of using Hospital Fit as part of the physiotherapy treatment on average time spent walking per day in patients hospitalised at the Medical Oncology or Cardiology Departments of the Maastricht University…
Aim of the studyThis is a proof-of-concept study to investigate the effects of rTMS (iTBS protocol) on working memory of people with memory impairments after a cardiac arrest in the past. We propose a series of single case experimental design (SCED…
In different stages of HCM, to measure the: - Myocardial perfusion- Myocardial function- Volume parameters of the heart- Fibrosis- Function of the small vessels (endothelial (dys)function)- Diastolic function and strain of the heart
- Enrolment of a representative cross-section of AF patients in Europe.- Detailed analysis of clinical and relevant parameters (digitalised ECG, cardiac imaging, blood biomarkers) that could be used during clinical practise for the diagnosis of…
Primary Objective: to derive iPSCs from patients with a variety of diseases caused by genetic mutations or genetic predisposition to disease or of unknown origin. The cells will be propagated and differentiated into a variety of somatic cell types…
Objective: Our main objective is to assess in detail risk factors for cardiovascular disease and cardiotoxicity and to compare heart function parameters, vascular parameters and biomarkers associated with cardiovascular function among 5- to 18-year…
CONCRETE aims to: (1) evaluate whether GP access to CT calcium scoring leads to earlier CAD diagnosis and treatment, (2) assess and optimize gender-specific diagnostic stratification based on the calcium score, (3) determine which (cluster of)…
Primary objectives: The first aim is to examine the role of microtubule network in electrical conduction, protein localization and function in induced cardiomyocytes from pediatric BrS patients, life threatening ventricular arrhythmia patients and…
The main aim of this study is to improve knowledge on the hemodynamic burden of labour in women with cardiac disease and women without cardiac disease, by examining CO trajectory through the full course of labour. Therefore, we specified the…
The general objective is to study gender differences in the magnitude of CRT response in a HF population with an equal distribution of women and man in order to examine the interrelationship among CRT effect, gender and baseline clinical factors (e.…
The objective in the vanguard phase of the LIMIT trial is to assess the feasibility of recruiting 400 subjects over approximately 3 years at 5 centres. The objectives in the full trial are to evaluate the safety and efficacy of a common, lower INR…
To determine whether a standardized exercise workload elicits a different response on 1) metabolites/cardiac biomarkers in the general circulation (measured by blood values), and 2) contraction patterns in local myocardium (measured by…
The primary objective of the registry is:To analyse coronary artery disease progression with or without coronary artery bypass grafting.The secondary objective of the registry is:To report graft patency following bypass grafting of diffusely…
The main objective of the current study is to investigate platelet reactivity and underlying mechanisms using the novel multi-microspot analysis in a group of patients with SIHD and a healthy control group.
To identify arrhythmogenic electromechanical risk profiles in LQTS patients; in baseline conditions and during provocation; the recognition of risk profiles will improve risk stratification for sudden cardiac death.
Primary Objective(s):1. To study the presence and extend of exercise intolerance in male, female FD patients with classical FD and men with non-classical FD, in different stages of the disease.2. To determine the aetiology of exercise intolerance in…
We aim to investigate if aortic stiffness, measured by pulse wave velocity (PWV), is present in patients with DMD and whether treatment with ACEi reduces aortic stiffness.