100 results
The aim of the present study is a performance evaluation of INNOVANCE® PFA P2Y. The first objective is the determination of a reference interval for the Intended Use Population (patients eligible for Clopidogrel therapy). This will be done by…
Primary objective: To investigate whether urine prothrombin fragments are increased in individuals suffering from VTE (i.e. PE or DVT) or a myocardial infarction compared to healthy matched controls.Secondary objective: to investigate whether…
- To detect carotid and aortic plaque morphology and long term plaque behaviour in patients with cerebral and cardiac end-organ damage (NSTEMI / STEMI and TIA / CVA) with 1.5T MRI-derived virtual histology and relation to biomarkers.- To correlate…
To establish whether miRNA expression patterns in platelets, monocytes, plasma and endothelial cells differ between subjects with premature CVD and a positive family history of premature CVD as compared to age en sex matched healthy controls.
The goal of this study is to find an efficient early diagnostic and prognostic marker of myocardial ischemia and myocardial infarction. Extended screening of gene expression profiles in circulating progenitor cells in the peripheral blood of…
Objective:The hypothesis of this study is that laboratory markers for blood coagulation, platelet activity and inflammation may help to identify patients at risk for a recurrent cardiovascular event after ACS. Secondary, we expect to find…
Primary Objective: a) Do EC/SMC from patients with cardiovascular disease and renal failure have inferior reproductive capacity compared to cells from control donors?Secondary Objectives: a) What is the interindividual variation of cultured…
The goal of this study is to determine if off-pump CABG surgery is associated with better cerebral tissue oxygenation when compared with on-pump CABG. In addition, we would like to compare the results of two different monitors of brain tissue…
To further investigate the application in a clinical setting we aim to set up a model in which we can investigate the protective effects in an in vitro model, where subjects blood serum is used to transfer the protective effect of RIPC onto cells…
The results of these studies will provide a possible explanation for the increased risk of cardiovascular events in patients with PHA. Our study is the first to explore the hypothesis that patients suffering from PHA are more vulnerable to IR injury…
We will investigate if irradiation of part of the heart leads to cardiac sympathetic innervation injury and subsequently to radiation induced cardiovascular disease.
This study evaluates if there is a difference in platelet function during and following the use of minimal ECC compared with conventional ECC in coronary artery bypass grafting (CABG) analysed with tromboelastography en multiple electrode aggrometry…
The main objective is to study whether patients with coronary atherosclerosis show increased H3K4 trimethylation in the promoter regions of pro-inflammatory cytokines and have an augmented ex vivo TLR agonist-induced cytokine production in isolated…
To assess the impact of six IV infusions of 3, 6, or 12 mg/kg of CER-001 or placebo, given at weekly intervals, on atherosclerotic plaque volume, as measured by coronary IVUS.
Primary Objective:Proof of concept study designed to document the safety and feasibility of adjuvant treatment with the PICSO Impulse system in patients with acute anterior ST-segment elevation myocardial infarction (STEMI) treated with primary PCI…
Primary Objective: comparing hemodynamic stability provided by titration of esmolol in addition to standard perioperative care including low-dose metoprolol to placebo and standard care.Secondary Objective(s): -comparing the incidence of…
The aim of this clinical study is to determine, what the effect of RBC transfusion is on the microcirculation after cardiac surgery in the ICU, as compare to asanguineous colloid (Gelofusine®) infusion.
Our primary objective is to measurec glycocalyx volume with OPS imaging, before and after sublingual nitroglycerine-spray administration, in patients with premature atherosclerotic disease before the age of 40 years and a positiev family history for…
To investigate whether IC administration of abciximab during primary PCI is superior to IV administration in improving myocardial perfusion in patients with STEMI.
This study is focused on determination of risk factors associated with preeclampsia and intrauterine growth restriction, both develop in early pregnancy. These pregnancy complications are associated with cardiovascular diseases in later life. We…