100 results
To investigate the relation between premature cardiovascular disease and glycocalyx perturbation
1) To asses heparin-induced LPL release curves in patients with the Mets 2) To determine differences in gene expression of LPL, GPIHB1 and ANGPTL4 in muscle and adipose tissue of patients with the MetS compared to health controls3) To determine…
This study finally aims to provide hospitalized coronary heart disease patients who smoke with proven (cost)effective smoking cessation interventions. Point prevalence abstinence is estimated in the experimental groups at 60% at 6 months, against 43…
a) To investigate the differences in adipokines and inflammatory markers between obese and normal weight children; b) to study these differences over age, and c) to correlate adipokine/inflammatory marker profiles to clinical parameters for obesity…
To establish whether miRNA expression patterns in platelets, monocytes and plasma differ between subjects with premature CVD and a positive family history of premature CVD as compared to age en sex matched healthy controls.
Hypothesis:1. Patients who suffer from a hypopituitarism and an adult-onset growth hormone deficiency (AGHD) express more atherosclerotic disease in the coronary system (compared with a historically formed control subjects, present as a database in…
Our primary objectives are to evaluate - if endogenous EPO, EPC levels and EPC function are different in patients with stable and unstable CAD, compared to age and sex matched controls;- if a correlation exists between endogenous EPO and EPC levels…
Objective: We aim to assess whether [1] epigenetic alterations are responsible for the detrimental effects of maternal undernutrition during gestation on the offspring*s (F1) cardiovascular health, and [2] these epigenetic alterations pass down…
1. To evaluate whether patients with FCH have different pattern of hypothalamic neural activity compared to healthy control subjects, 2. To evaluate whether patients with FCH (index patients) have a different pattern of hypothalamic neural activity…
The main objective of this study is to determine the role of glycaemic control in diabetes mellitus in the occurrence of acetylsalicylic acid resistance, the secondary objective is to determine the effect of increased dosing on acetylsalicylic acid…
In this study we will test the study hypothesis whether there is differential gene expression between patients with a history of premature MI and healthy controls when testing RNA obtained from highly purified platelets and monocytes.
The aim of the present study is to investigate if FFR measurement of a stenosis in a remote coronary artery are influenced by the presence of acute myocardial infarction.
We set out to evaluate the genetic basis of dyslipidemia and cardiovascular disease.
Our objective is to measure systemic glycocalyx volume in patients with premature atherosclerotic disease before the age of 40 years and to compare this with a age and sex matched healthy control group.
Our aim is to characterize the functional properties of circulating cells (monocytes, lymphocytes, and progenitor cells) in patients with chronic coronary artery disease (CAD) and acute myocardial infarction (AMI). Likewise, we wish to characterize…
To assess long-term safety and tolerability of pitavastatin 4 mg once daily (QD)To assess the efficacy of pitavastatin (4 mg QD) and simvastatin (40 mg and 80 mg QD) in terms of LDL-C target attainment (European Atherosclerosis Society [EAS] and…
To assess long term safety and toleralibility of Pitavastatin 4 mg QD. To assess the efficacy of Pitavastatin (4 mg) and simvastatin (40 mg and 80 mg QD) in terms of LDL-C target attainment (EAS and NCEP) following 16 weeks and 44 weeks of treatment…
To study whether ticagrelor, added to acetylsalicylic acid, modulates the inflammatory response to the administration of lipopolysaccharide (LPS) in humans in vivo.
To assess the plasma arginase level and arginase activity in time in patients with evidence of ischemia.