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Ki-67 and cytokeratin 16 expression in several lesion types of hidradenitis suppurativa compared to keratosis pilaris and psoriasis inversa. A pilot investigation

To investigate whether the upregulation of CK16 and Ki-67 (a marker for cell proliferation) in the FPSU is specific for HS, measured in inflammatory nodules and pseudo-comedones, in comparison to other dermatologic conditions that have comparable (…

THE MORPHOLOGY OF THE BASEMENT MEMBRANE ZONE OF HAIR FOLLICLES IN HIDRADENITIS SUPPURATIVA: A PILOT STUDY

To describe the composition of the BMZ along the interfollicular and follicular epidermis of perilesional HS skin and to investigate whether the expression of these proteins differs from normal skin of healthy control patients. Additionally, a…

Short term clinical efficacy of topical treatment with clindamycin-benzoyl peroxide gel compared with clindamycin lotion in mild to moderate Hidradenitis Suppurativa

Therefore the primary objective of this study is to evaluate the effect of twice daily application of topical clindamycin1%/benzoyl peroxide 5% gel compared with the standard treatment with topical clindamycin1% lotion on the frequency of active…

Differences in unaffected skin of patients with hidradenitis suppurativa compared with healthy controls.

To compare the microbiome, histology, immunohistochemistry and gene expression profile of healthy skin from the axillae or groin of 10 healthy volunteers with uninvolved axilla or groin skin from age, gender, body mass index, and smoking status…

An open-label, long-term extension trial of spesolimab treatment in adult patients with Hidradenitis Suppurativa (HS)

The primary objective of this trial is to assess the long-term safety of spesolimab in patients with HS who have completed the 1368-0052 PoCC trial and are qualified for entry into this trial. The secondary objectives are to evaluate efficacy at a…