187 results
Primary: Does immunomodulation brought about by interferon beta-1a (Rebif) enhance or prolong functional reorganization in subjects with RRMS?Secondary: Does interferon beta-1a (Rebif) also affects functional connectivity as measured by resting-…
Our aim of the study is investigate IL-7, TSLP and CD30(L) expression in SLE patients en healthy controls to better understand pathogenesis and to find a biomarker that is related to disease activity.
Development, optimization and implementation of retro-orbital fibroblast cultures in our laboratory.
1. To determine, in patients treated with TNF α blockers and living in the Q-fever endemic area, the prevalence of antibodies against C. burnetii and the prevalence of chronic Q fever.2. To assess other determinants in this group of patients which…
zie boven
Primary objectiveTo determine whether a second IVIg dose in GBS patients with a poor prognosis improves functional outcome after 4 weeks.Secondary objectives To investigate whether: - a second IVIg dose in GBS patients with a poor prognosis improves…
Confirm an association between RA and periodontitis and unravel pathogenic mechanisms underlying this association.
This research aims the usefullness of duplex mapping in systemic giant cell vasculitis. In determing the diagnosis, the duplex will be compared with the current gold standard, the 18F-FDG PET-CT, looking at the sensitivity and specificity of the…
The main hypothesis is that circulating inflammatory mediators are the main causative factor for the emergence of generalized osteoporosis in patients with Rheumatoid Arthritis (RA). 1.Does the serum of patients with active RA, containing…
The aims of the present study are 1) to confirm the high prevalence of dRTA in Sjögren using the urinary acidification test with ammonium chloride, 2) to determine the prevalence of disorders in calcium metabolism in pSS patients with dRTA, 3) to…
The objective of this study is to understand the patient perspective on remission in RA.
to investigate functional characteristics of immune cells from MS patients, including migratory capacity, inflammasome activity and Breg cell function and compare these to healthy control subjects 2) to assess possible differences with regard to the…
To answer the following questionsDo RA-specific autoantibodies cross the placenta, and can they be found in fetal cord blood in the offspring of mothers suffering from RA?Do RA-specific autoantibodies in fetal cord blood display different…
To investigate the differences in short-chain fatty acid metabolism, markers of local (intestinal) and systemic inflammation and markers of bacterial translocation between type-1-diabetes patients and healthy controls and to relate these differences…
To investigate LN cellular composition and functional aspects of lymphnodes in pre-clinical patients eventually developing RA compared to patients that do not develop RA, and of lymphnodes of early RA patients compared to non-RA patients, all…
In this project we will perform lymph node tissue analyses in 1) autoantibody-positive individuals who are at risk of developing RA, 2) early arthritis patients who do (RA) or do not (yet) (unclassified arthritis, UA) fulfil 2010 ACR/EULAR…
Primary objective: To evaluate the influence of pSS on sexual function, as measured by the female sexual function index (FSFI), in comparison to a healthy control group. Secundary objective: To evaluate the influence of pSS on subdomains of sexual…
This project intends to study the biology of B cells in arthritis. B cells are important components of the human immune system and have several functions. Next to the production of antibodies, B cells can function as efficient antigen presenting…
The end-points of this study are:1. To evaluate the prevalence of dRTA in Sjögren using a new screening test with furosemide and fludrocortisone and compare this against the gold standard test with ammonium chloride2. To determine the prevalence of…
To evaluate the reproducibility of the SvdH score (BE and JSN of one hand) of radiographs taken with a mould compared to conventionally acquired images.