187 results
The present clinical study is part of the development and evaluation of the Full Hand Proto (FHP) to measure disease activity in the joints of hands and wrists of rheumatoid arthritis patiens based on optical attenuation measurements.
Our overall objective is to better understand the role of regulatory B cells in disease pathogenesis and to better predict disease flares in order to individualize treatment.
Primary:To investigate the presence of disease-specific antimyenteric antibodies and to identify their target-antigen in patients with achalasia.Secondary:- To determine to what extent humoral autoimmunity is the etiological factor in idiopathic…
The aim of this study is to develop an immortalised B-cell line derived from MG patients. This antibody producing cell line will be used for different applications:- The establishment of new passive transfer disease models for MG- The identification…
To evaluate two biomarker tests (characterized by an activated inflammatory response system (IRS) as reflected by an aberrant monocyte gene expression signature and/or a disturbed metabolism of tryptophan) by comparing patients with BD with healthy…
The objective of this pilot study is to provide information about the usefulness of NIRS in the study of patients with JDM in the test configuration as described in the protocol. For this purpose, the microvascular oxygenation and hemodynamics in…
This study concerns a research that is aimed to investigate the prevalence of the metabolic syndrome in a group of patients known with ANCA-associated vaculitis. Hereby we will compare the presence of the metabolic syndrome between an ANCA-…
To gain more insight into the pathogenetic processes involved in SS by analyzing the infiltrate and structural changes in salivary glands of SS patients and compare these findings to those in other (aspecific) inflammatory and non-inflammatory…
Primary objectives:• To explore whether daily oral treatment with 30 mg prednisolone modulates biomarkers for adverse metabolic effects in a similar manner in patients with chronic atopic dermatitis as compared to healthy volunteers.• To determine…
In this project we will set out to investigate characteristics of the aged immune response, with a particular focus on the role of microRNAs (miRNAs) herein. Specifically we will address two aims:1) We aim to characterize the differences in the…
This research project aims to investigate the interaction between systemic immune cells and cells from the glandular tissue of patients with Sjögren's syndrome and sicca syndrome. We hope to obtain more insight in the cause and persistence of…
The aim of the proposed study is to get more insight into the role of the hippocampus and thalamus in cognitive impairment in MS patients. To achieve our goal, we propose to study the (abnormal) structure and function of the two structures with…
The research strives for a large group of homogeneous AID patients, so that a powerful association study can be performed to detect genetic risk factors. These factors can be shared by several AIZ, or be specific is for a single AID. The aim of this…
First, to develop a diagnostic method for non-infectious uveitis in childhood. Second, to analyze iris and ciliary body tissues of children with uveitis on the presents of inflammatory infiltrate. The results of this study will contribute in the…
To establish efficacy of pre-travel vaccinations by determination of protective serum antibody titres against hepatitis A, DTP and polysaccharide Vi of Salmonella typhi. To quantify health risks related to preventive actions and consequences of…
Primary Objective: characterization of GPBP expression on different subsets of human leukocytesSecondary Objective: functional characterization of GPBP on these cells
In the present research we will focus on the role of nutrition in the relationship between depression and coeliac disease.
1) To investigate the VDR levels in different MS associated T cell subsets2) to compare the VDR levels in the different T cell subsets between MS patients and age and gender matched healthy volunteers
To demonstrate and compare expression of CCL25 and CCR9+ lymphocytes in peripheral blood and colon of PSC-, PSC/IBD-, IBD-, gastroenteritis patients and controls.
To determine whether a second, booster, influenza vaccination leads to a higher seroprotection rate in SLE patients, as compared to a single vaccination.