187 results
In the coming months, immunocompromised patients treated in our hospital will be requested to undergo vaccination if they comply with the National Institute for Public Health guidelines. For all subgroups, it is of utmost importance to assess the…
To identify new biomarkers for the prediction of disease outcome, resulting in the identification of prognostic tools and markers to monitor treatment response. Furthermore, the underlying pathways in systemic autoimmune diseases shall be evaluated…
The aim is to investigate the therapeutic effects of Secukinumab on bone formation in SpA patients by using [18F]Fluoride PET-CT imaging, and to investigate cellular and molecular pathology in bone formation.
To understand walking-related factors that contribute to fatigue and the relationship with total physical activity and social participation in daily life among pwRA and pwOA.
The aim of this pilot study is to explore the structure and function of brain regions associated with the pain matrix in Breast Implant Illness (BII). This pilot study will be the foundation for grant application for future research.
Primary objective1. The primary aim of the study is to answer the question whether specification of a positive direct antiglobulin test and/or red blood cell autoantibody specification is correlated with the clinical course in patients with AIHA. We…
1. To identify immunological alterations in peripheral lymphoid/skin/synovial tissue of patients with psoriatic artritis and psoriasis2. To correlate these alterations with disease stage, prognosis, treatment response3. To compare immunological…
The goal of this study is to identify and validate recently discovered and novel biomarkers of pathophysiology, diagnosis, classification, disease activity, prognosis, treatment susceptibility, and treatment efficacy in IMIDs.
to characterize the endometrial immune environment in patients with SLE
Hand function impairment in systemic sclerosis: Outcomes, Mechanisms and Experience (HANDSOME) study
Primary Objective: Determination of risk factors for hand function impairment in systemic sclerosis (SSc) patients with early disease, very early disease and established hand impairment (contractures) at 2 years follow-upSecondary Objective(s):-…
The primary objective is to characterise and understand the heterogeneity in patients with ME/CFS (i.e. comorbidities, variability in symptoms and disease progression, severity, and cognitive and autonomic impairment). Therefore, the secondary…
The overall aim of this project is to unravel the role of IFN-I in ILD in the known/classified SADs and in ILD with autoimmune features but without a specific SAD diagnosis (IPAF), with as ultimate goal better treatment. Since 13-40% of ILD patients…
Primary Objective:Our primary objective is to generate in-depth immune profiles, which include phenotypic and functional analyses, as well as epigenetic and transcriptomic analyses, of several B cell, T cell, and monocyte subsets, which relate to…
The objective of this study is to investigate of inflammatory tissues of patients with SSj, CLE and SSc contain autoreactive B and T cell expansions that are differently activated compared to other B and T cell expansions in patients with SSj, CLE…
- To compare the course and determinants of the SARS-CoV-2-specific humoral and cellular immune response in AID patients upon primary SARS-CoV-2 infection to that in healthy controls (HC)- To determine the seroconversion rate, magnitude and…
The primary goal of this study is to identify the presence and possible pathogenic role of auto-antibodies in scleritis patients. Secondary goals are to evaluate the presence and role of matrix metalloproteinases (MMPs) in scleritis and its…
The first objective is to explore the biological profile (e.g. the immunological profile, hypothalamic- pituitary-adrenal (HPA) axis, mitochondrial dysfunctioning, the gut microbiome) of adolescents with QFS and related fatigue disorders (CFS/ME,…
To evaluate the tofacitinib and infliximab treatment-induced changes in plasma lipids and lipoproteins and to provide insight in the underlying mechanism in relation to the inflammatory status in patients with active UC.
The primary goal of this study is to identify immunological alterations in lymphoid tissue of patients with various forms of inflammatory arthritis and systemic inflammatory diseases, and to correlate these alterations with diagnosis, disease stage…
1) To study whether local inflammation is present in patients with Clinical Suspect Artralgia and detectable with dedicated extremity MRI2) To identify determinants (imaging but also serological, genetic factors) for progression to clinical…