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Preterm Immune system development and response to Immunization

Primary objective is to study the antibody immune response to routine vaccinations in very preterm infants (GA<32 weeks). Secondary aim is to study the immune system more extensively using flow cytometry, ELISA and single cell transcriptomics…

Impact of Alemtuzumab exposure on immune reconstitution, autoimmunity, risk of infection, chimerism and Graft-versus-Host Disease in children with non-malignant diseases undergoing allogeneic stem cell transplantation. ARTIC International Multicenter Observational Study.

Primary objectiveTo evaluate current clinical practice and develop a population based Campath® (Alemtuzumab) pharmacokinetics model for predicting total Alemtuzumab exposure after i.v. administration before allogeneic stem cell transplantation in…

Single-cell analysis of somatic mutations to understand and improve blood formation after hematopoietic stem cell transplantation

We aim to quantify the contribution of individual HSCs to blood (re-)generation in pediatric HSCT recipients and their donors, and to unravel the consequences of transplantation on HSC long-term genomic integrity.

Primary Immunodeficiencies:
immunological and genetic background in relation to clinical complications

Project aims1. To provide a more precise overview of prevalence, presenting symptoms, referral routes, clinical complications and evolution during follow-up of PIDs in The Netherlands by registration and analysis of prospective patient data derived…

Vaccination Against Covid in Primary Immune Deficiencies

To assess immunogenicity and safety of SARS-CoV-2 vaccination in patients with isolated antibody deficiencies, i.e. patients with immunoglobulin G (IgG) subclass deficiency and patients with selective antibody deficiency with normal immunoglobulins…

Genetic Risk factors for Multi-system Inflammatory Syndrome in Children and Pediatric Post COVID condition (GRIP)

Primary objective: To identify rare, high impact genetic variants in immunological genes and pathways in children with a history of MIS-C or pediatric post-COVID condition. Secondary objectives: To analyze the clinical characteristics and long-term…

Neurological, cardiovascular, visual and neurocognitive performance in pediatric HIV-1- infected patients as compared to healthy controls NOVICE - III a follow up study

This study is a follow-up study of the NOVICE I & NOVICE II (METC 2012_093 and METC 2016_173). The objective of the study is to both cross-sectionally and longitudinally, after an interval of 10 years, gain more insight into the presence,…

NATURAL KILLER CELL RECEPTOR VARIABILITY DURING THE MENSTRUAL CYCLE

The main goal of this study is to analyse the influence of the menstrual cycle on NK cell receptor variability.

Severe COVID-19 In Pregnancy (SCIP): a pilot study
Linking disease severity to the maternal immune composition

To identify differences in immune cell repertoire between pregnant women with critical COVID-19, mild COVID-19 and healthy controls.

Registering the immune response to an influenza vaccination challenge in PTEN Hamartoma Tumour Syndrome

Primary Objective: The primary objective is to analyse the humoral and cellular immune response to influenza vaccination in PHTS individuals.• Is the immune response to seasonal influenza vaccinations impaired in PHTS?• Do characteristics in humoral…

Sequelae of acute hepatitis C virus infection among HIV positive MSM, HIV negative MSM and HIV positive heterosexuals: the MOSAIC cohort.

To study a cohort of HIV infected and HIV uninfected MSM and HIV infected heterosexuals who (subsequently) acquired HCV infection with a known date of HCV seroconversion:1. To identify the frequency, clinical consequences and determinants (viral and…

Fungal infections as complication of monoclonal antibody therapy directed against IL-17 mediated inflammation: estimating incidence and severity and identifying influence of immunogenetics to establish a guideline for screening, prevention and treatment.

1. To estimate the incidence and severity of fungal infections during anti-Th17 mAb therapy2. To characterize the determinants (clinical, immunological, mycobiome/microbiomeand genetical) for developing fungal infections during anti-Th17mAb therapy…

Study on Sophia HIV infected Children Cohort

1. Evaluation of neurocgnitive functioning in children with HIV in comparison with healthy siblings using questionnaires.2. Qualitative analysis of different determinants that play a role in school participation in children with HIV using interviews…