51 results
To examine the effect of BCG vaccination on the composition and function of the bone marrow.
Objectives1.3.1 Primary ObjectiveCompare the efficacy of BMS-945429 versus placebo for induction of clinical remission (defined by an absolute Crohn*s Disease Activity Index [CDAI] score < 150) at Week 8 (IP-57).1.3.2 Secondary Objectives•…
Our hypothesis is that antibodies of COPD patients contribute to inflammatory processes leading to cell death, and that the level of cytotoxicity differs between COPD patients and healthy volunteers. The prime aim is to detect differences in…
To get more insight into the T cell homeostasis in lymfocytopenic, ATG treated patients and normocytopenic patients treated with standard maintenance immunosuppressive drug therapy.
1. To describe the development of the nature of the immune system in early life in a profile of cytokines, chemokines and adipokines. 2. To evaluate less invasive methods like the use of saliva or less demanding methods like the use of dried bloods…
Our objective is to assess whether patients with SM compared to controls have more advanced atherosclerosis assessed by carotid intima-media thickness (C-IMT) and carotid plaques and have a more adverse cardiovascular risk profile.
Has the supplementation of oligosaccharides in the first year of life an effect on the incidence of atopic diseases and infections from the 5th until the 7th year of life in healthy children
Primary Objective: The main objective of this study is to analyse the effects of pregnancy on levels and percentages of CD8 cell subsets in peripheral blood both during and after pregnancy.
The main objective of this study is to1) Determine the immunological response to hepatitis B vaccination in OCD patients that are treated with 60 mg/d paroxetine and2) Compare this response to the immunological response to hepatitis B vaccination in…
Observational part on respiratory parametersThe primary objective of this study is to study the effect of hypothermia and rewarming on P/F ratio as a measure of oxygenation and on end tidal CO2 as a measure of ventilation during mechanical…
To investigate the relation between a known genetic variation in a set of selected genes involved in the recognition of microorganisms and inflammation and the frequency of respiratory tract infections in a group of children with DS.
The primary objective is whether a difference in innate and acquired immunorespons on RSV infection exists, in children with DS compared to healthy matched-controls.
We need objective and validated tests for the assessment of the severity of impairment in CFS/ME patients. In 2 areas these tests will be essential: for studies of the effect of interventions and for the assessment of disability.Hardly any research…
Objective of this study is to provide evidence for the induction of AGEs in blood and tissue in patients with septic shock.
To evaluate immune function and (the susceptibility for) oxidative damage under the influence of long-term olive-oil based TPN use in patients without an active underlying disease and compare this with findings in healthy controls
This study will investigate fatigue after exercise in sarcoidosis patients. It will determine the severity of their fatigue, the recuperative capacity after maximal exertion (bicycle ergometer) and the levels of ACE and cytokines (before and after…
The general objective of this study is to elucidate the cellular components for HIV-1 infection in children.
To select T cell properties intrinsic to the transplant recipient, which can discriminate between patients who will likely experience acute cellular rejection episodes from those who don*t.
Overall aim: To study the influence of M.leprae antigens on differentiation and maturation of DCs and to identify M.leprae antigens, receptors on antigen presenting cells and signaling pathways which play a role in leprosy pathology. Main objective…
The main objective is to identify a difference in mRNA expression level of IFN and IFN related genes between Down Syndrome children and a control group of healthy children (siblings). The secondary objective is to identify a relationship between…