271 results
The first objective is to explore the biological profile (e.g. the immunological profile, hypothalamic- pituitary-adrenal (HPA) axis, mitochondrial dysfunctioning, the gut microbiome) of adolescents with QFS and related fatigue disorders (CFS/ME,…
PrimaryTo evaluate the safety and tolerability of single and multiple doses of TBAJ-587 in healthy participants.SecondaryTo determine the pharmacokinetics (PK) of single and multiple doses of TBAJ-587 and metabolites M2, M3 and M12. To compare the…
Primary objective: The primary objective of this study is to investigate if taking methenamine hippurate reduce the need for antibiotic usage due to recurrent UTI (measured as the number of courses of antibiotics).Secondary objectives:to investigate…
- To compare the course and determinants of the SARS-CoV-2-specific humoral and cellular immune response in AID patients upon primary SARS-CoV-2 infection to that in healthy controls (HC)- To determine the seroconversion rate, magnitude and…
To further study the mechanisms responsible for the Borrelia induced inhibition of antigen presentation and the impaired immuneresponse in Lyme disease pat¡ents, we would like to assess the immunological changes that occur in patients with a…
The goal of this study is to develop a flow-cytometric assay that is able detect antigen-specific B-cells to rabies vaccine.
To investigate the safety and tolerability of GSK2556286 after single ascending and repeat oral doses in healthy adult participants.To determine the pharmacokinetics of single and repeat oral doses of GSK2556286 in healthy participants.To assess the…
The key objective of the study is to characterize the immune response against SARS-CoV-2 omicron variant. Secondary objectives:1. Does the clinical course of disease correlate to viral loads and the immune response?2. How is the CT value of the PCR…
Identifying the pro-inflammatory biomarker profile in the pathophysiology of acute sever lung disease in SARS-CoV-2 infection, and using this profile to identify the patients who are at risk of developing acute severe lung disease and multi-organ…
Primary objective: To evaluate, in a cohort of non-tested individuals who reported flu-like symptoms during the COVID19 epidemic in the Netherlands (March-November), the seroprevalence of COVID19 in patients with an IMID, with or without…
In this study, we therefore aim to establish the kinetics of the humoral immune response against SARS-CoV-2, and relate this to the viral characteristics, microbiome and host factors of healthcare workers.
The primary aim of this study is to investigate the effect of honey on the clearance of the hr-HPV virus in patients with CIN II.Secondary, the effect of honey on the normalization of CIN lesions, the role of the vaginal microbiome, the local immune…
To answer the following questions: 1. Who are the patients that need to be revaccinated?2. How many vaccinations are needed to restore SARS-CoV-2 immunity?3. Can the number of vaccinations needed to restore SARS-CoV-2 immunity be predicted?To answer…
Primary Objective: - To assess the effect of MMR-0 vaccination on the humoral immunity against measles 2 years (+/- 2 months) after MMR-2 vaccination.Secondary Objective(s): - Determine the effect of MMR-0 vaccination on the humoral immunity against…
The objective of this study is to determine the immune response after hepatitis A and pneumococcal vaccination in different groups of ICPs. The overarching aim of the study is to improve vaccine regimens and to optimize guideline recommendations…
OBJECTIVESPrimary ObjectivesThe primary objective is:* To assess the safety and tolerability of 6 weeks of treatment with RO7020531 administered orally to virologically suppressed chronic hepatitis B (CHB) patients.Secondary ObjectivesThe secondary…
We aim to determine the impact and seriousness of other TBDs in the Netherlands by measuring the prevalence and describing the clinical picture and the course of different other TBDs.
Our main aim is to develop a biomarker-based method to decide whether treatment with antibiotics is required for treatment of individual hospitalized AECOPD patients. We hypothesize that our biomarker-based intervention, using PCT levels to guide…
To determine the efficacy of oral fosfomycin in comparison to the standard of care oral ciprofloxacin, in the treatment of FUTI after initial empirical treatment with intravenous antibiotics.To describe the pharmokinetic profile of men treated with…
To obtain insight whether skeletal muscle adaptations can explain post-exertional fatigue malaise in patients with PASC and ME/CFS, the present study will address the following objectives: Primary objectives:• To determine markers for skeletal…