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Nontuberculous mycobacterial cervicofacial lymphadenitis in children; diagnostic performance of the Capilia MAC antibody Elisa test and possible portals of entry

This study intends to investigate the diagnostic potential of the Capilia mac antibody Elisa test in children with a clinical suspicion of NTM cervicofacial lymphadenitis.Moreover, this study aims at investigating whether NTM possibly access the…

Long-term outcomes of pulmonary function in HIV-infected patients with a history of Pneumocystis jirovecii pneumonia

Assessing the prevalence of pulmonary function testing abnormalities in HIV-infected patients with and without a history of PJP.

Precision use of Antibiotics in Infected Necrotizing Pancreatitis

The primary objective is to determine whether implementation of a best-practice protocol focused on antimicrobial stewardship in Dutch hospitals is non-inferior compared to standard care on mortality and major complications in patients with acute…

Meningitis sequelae in Adulthood: Towards and Understanding of Residual Effects after childhood bacterial infection

The project will aim to quantify very long-term sequelae after childhood BM (~31 years after infection) on a wide range of functional outcome domains: neurocognitive functioning, behavioral and emotional functioning, health related quality of life,…

Unravelling the measles paradox: a disease associated with both immune suppression and immune activation

Unravelling the *measles paradox* by in-depth characterization of the immune repertoire before and after natural measles or measles vaccination.

Identifying mucosal defence mechanisms against viral infections in patients with COPD and consequences for the development of exacerbations

We aim to characterize innate anti-viral defence responses in the upper airways of COPD patients.

Changes in host gene expression to differentiate between systemic inflammation and infection after major surgery (PAX study)

Primary Objective: To study the early diagnostic performance of specific gene signatures for differentiation of patients having postoperative infection (A1) or sepsis (A2) from non-infected patients having postoperative SIRS (B1) and non-infected…

Characterization of aberrant immune response in post-COVID using innovative signal transduction pathway technology (LC-STP)

Research objective: Transcriptome data from main immune cell types (monocytes, CD4+ and CD8+ T cells, B-cells, NK cells) of post-COVID patients are analyzed using STP technology. STP-activity results are interpreted in combination with clinical…

Exploring the early healing potential of a novel thermosensitive hyaluronic acid gel with octenidine preservation system as an adjunct to non-surgical periodontal treatment: a split-mouth blinded pilot study with proteomic analysis

This pilot study aims to assess the feasibility, safety and preliminary efficacy of a novel thermosensitive hyaluronic acid gel with an octenidine preservative system as an adjunct to standard non-surgical periodontal treatment. The use of a blinded…

Non-interventional study to investigate the transfer of vaccination induced maternal antibodies in infants with fetal growth restriction.

The aim of this study is to investigate whether the transfer of antibodies from mother to infant is less effective in infants with intrauterine growth restriction (FGR) compared to term-born infants without intrauterine growth restriction or who are…

SARS-CoV-2 antibody-mediated inflammatory responses by macrophages in individuals with and without obesity

To study anti-SARS-CoV-2 antibody-mediated inflammatory responses by macrophages in individuals with obesity.