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Unravelling the measles paradox: a disease associated with both immune suppression and immune activation

Unravelling the *measles paradox* by in-depth characterization of the immune repertoire before and after natural measles or measles vaccination.

Identifying mucosal defence mechanisms against viral infections in patients with COPD and consequences for the development of exacerbations

We aim to characterize innate anti-viral defence responses in the upper airways of COPD patients.

Skeletal muscle structure and function in relation to post-exertional malaise in patients with PASC and ME/CFS

To obtain insight whether skeletal muscle adaptations can explain post-exertional fatigue malaise in patients with PASC and ME/CFS, the present study will address the following objectives: Primary objectives:• To determine markers for skeletal…

Nontuberculous mycobacterial cervicofacial lymphadenitis in children; diagnostic performance of the Capilia MAC antibody Elisa test and possible portals of entry

This study intends to investigate the diagnostic potential of the Capilia mac antibody Elisa test in children with a clinical suspicion of NTM cervicofacial lymphadenitis.Moreover, this study aims at investigating whether NTM possibly access the…

Long-term outcomes of pulmonary function in HIV-infected patients with a history of Pneumocystis jirovecii pneumonia

Assessing the prevalence of pulmonary function testing abnormalities in HIV-infected patients with and without a history of PJP.

Immunity against SARS-CoV-2 in immune-suppressed patients: increased risk of insufficient
immunological memory or sufficient protection against re-infection? A Target to B! substudy

- To compare the course and determinants of the SARS-CoV-2-specific humoral and cellular immune response in AID patients upon primary SARS-CoV-2 infection to that in healthy controls (HC)- To determine the seroconversion rate, magnitude and…

Borrelia-induced inhibition of antigen presentation: a novel escape mechanism from the host defense system.

To further study the mechanisms responsible for the Borrelia induced inhibition of antigen presentation and the impaired immuneresponse in Lyme disease pat¡ents, we would like to assess the immunological changes that occur in patients with a…

Detecting the antigen-specific B-cell-response to rabies vaccination.

The goal of this study is to develop a flow-cytometric assay that is able detect antigen-specific B-cells to rabies vaccine.

A randomised, double blind (sponsor unblinded), placebo-controlled, first time in human study to evaluate the safety, tolerability and pharmacokinetics of single and repeat oral doses and the food effect of GSK2556286 in healthy adult participants

To investigate the safety and tolerability of GSK2556286 after single ascending and repeat oral doses in healthy adult participants.To determine the pharmacokinetics of single and repeat oral doses of GSK2556286 in healthy participants.To assess the…

Immunity against SARS-CoV-2 Omicron variant

The key objective of the study is to characterize the immune response against SARS-CoV-2 omicron variant. Secondary objectives:1. Does the clinical course of disease correlate to viral loads and the immune response?2. How is the CT value of the PCR…

Biomarker-based Early Anti-inflammatory Therapy for severe COVID-19

Identifying the pro-inflammatory biomarker profile in the pathophysiology of acute sever lung disease in SARS-CoV-2 infection, and using this profile to identify the patients who are at risk of developing acute severe lung disease and multi-organ…

Influenza-associated pulmonary aspergillosis (IAPA) in ICU patients with severe influenza: incidence and host- and pathogen related risk factors

A prospective multi-center observational study to assess the incidence of influenza-associated pulmonary aspergillosis (IAPA) in ICU patients and to identify host- and pathogen related risk factors for IAPA in EORTC negative ICU patients with severe…

A study focused at identifying disrupted biological factors and
patient-tailored interventions for adolescents with Q-Fever
Fatigue Syndrome

The first objective is to explore the biological profile (e.g. the immunological profile, hypothalamic- pituitary-adrenal (HPA) axis, mitochondrial dysfunctioning, the gut microbiome) of adolescents with QFS and related fatigue disorders (CFS/ME,…

TBAJ-587-CL-001, Phase 1, Partially Blinded, Placebo-Controlled, Randomized, Combined Single Ascending Dose with Food Effect Cohort Trial (Part 1) and Multiple Ascending Dose Trial (Part 2) to Evaluate the Safety, Tolerability, and Pharmacokinetics of TBAJ-587 in Healthy Adult Participants.

PrimaryTo evaluate the safety and tolerability of single and multiple doses of TBAJ-587 in healthy participants.SecondaryTo determine the pharmacokinetics (PK) of single and multiple doses of TBAJ-587 and metabolites M2, M3 and M12. To compare the…

The effect of methenamine hippurate to reduce antibiotic prescribing due to new episodes of urinary tract infections (UTI) in elderly women with recurrent UTI- a triple-blinded, randomized placebo-controlled phase IV study

Primary objective: The primary objective of this study is to investigate if taking methenamine hippurate reduce the need for antibiotic usage due to recurrent UTI (measured as the number of courses of antibiotics).Secondary objectives:to investigate…

A PHASE I, SPONSOR-OPEN, INVESTIGATORBLINDED,SUBJECT-BLINDED, MULTI-CENTER,
PLACEBO-CONTROLLED STUDY TO EVALUATE SAFETY, TOLERABILITY, PHARMACOKINETICS
AND PHARMACODYNAMICS OF ORAL ADMINISTRATION OF RO7020531: (1). SINGLE
AND MULTIPLE ASCENDING DOSES IN HEALTHY MALE AND FEMALE SUBJECTS; (2). 6-WEEK
TREATMENT OF VIROLOGICALLY SUPPRESSED PATIENTS WITH CHRONIC HEPATITIS B VIRUS
INFECTION

OBJECTIVESPrimary ObjectivesThe primary objective is:* To assess the safety and tolerability of 6 weeks of treatment with RO7020531 administered orally to virologically suppressed chronic hepatitis B (CHB) patients.Secondary ObjectivesThe secondary…

Ticking on Pandora*s Box: a prospective case-control study into *other* tick-borne diseases.

We aim to determine the impact and seriousness of other TBDs in the Netherlands by measuring the prevalence and describing the clinical picture and the course of different other TBDs.

Changes in host gene expression to differentiate between systemic inflammation and infection after major surgery (PAX study)

Primary Objective: To study the early diagnostic performance of specific gene signatures for differentiation of patients having postoperative infection (A1) or sepsis (A2) from non-infected patients having postoperative SIRS (B1) and non-infected…

Characterization of aberrant immune response in post-COVID using innovative signal transduction pathway technology (LC-STP)

Research objective: Transcriptome data from main immune cell types (monocytes, CD4+ and CD8+ T cells, B-cells, NK cells) of post-COVID patients are analyzed using STP technology. STP-activity results are interpreted in combination with clinical…

Fucosylation of antibodies in multi-inflammatory syndrome in children after SARS-CoV-2 infection

To study the antibody response as a disease modifying factor in the context of COVID-19, we will compare the anti-CoV antibody composition, quality and interaction with immune receptors.