248 results
Quantify inflammatory response (through IL-8 production) of bronchial (both commercial available cells and cultivated brushed infant cells) when exposing these to gastric juice from: hospitalized Infants, before and during PPI treatment and age…
To describe the prevalence of enteropathogenic viruses in children with primary (CVID and CVID-like disease) and secundary immunodeficiencies and a potential relation between this prevalence and the development of auto-/allo-immune enteropathy.
The primary objective is to generate genome-wide miRNA profiles of patient material (tissue samples and blood). The secondary objectives are to compare miRNA expression profiles to investigate what role differences in miRNA expression have in the…
The aim of this study is to find a succesful treatment for functional abdominal pain in children and at the same time improve the quality of life of these children. A second aim is to reduce the hospital visits and with that the costs.
Primary: We hypothesize that in eosinophilic esophagitis gastro-esophageal reflux-induced epithelial barrier dysfunction facilitates passage of food-antigens through the epithelial barrier and subsequent increased exposure of antigens by dendritic…
The primary objective of this study is to evaluate the tumor response of stable disease (SD), partial response, or complete response at at 12 weeks (according to RECIST 1.1 criteria) in two separate cohorts representing molecularly distinct subsets…
The present study aims to extent the sparse knowledge on sexual function in IBD by 1) examining the prevalence of sexual problems in men and women with IBD (including Crohn*s disease and ulcerative colitis), 2) comparing this with the prevalence of…
What is the prevalence of depression and anxiety in children with asthma. Is this more frequent in asthma than in other chronic conditions like diabetes and Coelikie? And how compares this to healthy children in the same phase of life?
The aim of this study is to assess the change of ammonia exhaled in Helicobacter pylori (HP) positive patients compared with patients that are not HP infected after urea administration. In principle, in this pilot study, the results of Kearney et al…
1) To investigate what changes are present in skeletal muscle tissue of elderly gastric and colonic cancer patients (>80) compared with younger gastric and colonic cancer patients (<60) and compared to elderly controls and younger…
1) To identify chromosomal regions associated with the EoE-phenotype in a family with multiple affected family members. Subsequently these regions will be sequenced to detect causative gene(s).2) To describe the clinical characteristics of EoE-…
To compare the protein profile of Barrett*s mucosa with and without early neoplasia in ER specimens in epithelial and stroma aiming to identify a biomarker indicating presence of early neoplasia in BE.
Primary objective of this study is the identification of familial germline mutations in SPS. Secondary objectives are to get a better insight in the molecular pathway of SPS and associated colorectal carcinoma, to discriminate those family members…
With this study we want to investigate the possible correlation between pre malignant abnormalities in the colon and inflamation of the colonic mucosa in patients with long lasting (more than 8 years) diverticular disease.Patients included will…
Primary:To investigate the presence of disease-specific antimyenteric antibodies and to identify their target-antigen in patients with achalasia.Secondary:- To determine to what extent humoral autoimmunity is the etiological factor in idiopathic…
To investigate the underlying mechanisms of gastroesophageal reflux and gastroesophageal reflux symptoms in treated achalasia patients.
This research aims to assess the effect ofn completing an ACA-task on decision-making regarding short-course pre-operative radiotherapy in the treatment of rectal cancer in clinical practice.
To assess whether close rectal restorative proctocolectomy with IPAA has a better outcome regarding postoperative vaginal vasocongestion and reported psychological and sexual functioning then IPAA by TME restorative proctocolectomy.
The primary objective is to determine the feasibility of the in vivo sentinel node procedure in patients with colon carcinoma, during open and minimal invasive surgery.The secondary objective of the study is awareness and knowledge of (non)sentinel…
The aim of this study is to improve insight in potentially genetic factors contributing to the development of pyloric stenosis.We aim to investigate the association of the COL3A1 gene and pyloric stenosis because of concrete signs in the existing…