14 results
To identify pathogenic bacterial biofilms in UC-patients with and without neoplasia in tandem with host factors such as barrier defects and carcinogenic pathway activation in a prospective cohort study.
We aim to gain insight into the incidence and severity of CIPN and its influence on patient-reported outcomes (i.e. health related quality of life (HRQoL), disease-specific complaints, depression, fatigue, sleep problems) among a prospective…
Brown adipose tissue activity and energy metabolism in cachexia induced by cancer or chronic disease
To study BAT activity and energy metabolism in patients with cachexia induced by cancer or chronic disease.
The purpose of this study is to investigate the role of adipokines-secretion in visceral adipose tissue and its influence on the risk for esophageal adenocarcinoma. Examination of adipose tissue may provide important insight into mechanistic links…
The primary objective is to generate genome-wide miRNA profiles of patient material (tissue samples and blood). The secondary objectives are to compare miRNA expression profiles to investigate what role differences in miRNA expression have in the…
Primary objective of this study is the identification of familial germline mutations in SPS. Secondary objectives are to get a better insight in the molecular pathway of SPS and associated colorectal carcinoma, to discriminate those family members…
The present study aims to investigate genetic factors that contribute to the development of BE.
Is is possible to detect tumorcells in blood in patients with colon cancer with RT-q-PCR.
To determine which DC populations are present in esophageal tissue of patients with reflux esophagitis and BE. Relate the findings regarding DC populations to other pre-malignant gastrointestinal disorders (IBD).
Primary objective:To determine the relative risk of gastric cancer for genetic polymorphisms.Secondary objectives:- To determine the relative risk of gastric cancer for combinations of genetic polymorphisms, H. pylori virulence factors and lifestyle…
We aim to recognise potential genetic modifiers for mutations in PMS2. This will be approached through comparing a selection of CRC-related genes in the exome of members of a PMS2 family who differ in age of onset and severity of disease.
Primary Objectives:1. To compare protein synthesis rate of the tumour and normal pancreas between cachectic and non-cachectic patients with pancreatic cancer.Secondary Objective(s):1. To compare protein synthesis rate of liver, intestinal, adipose…
Lynch-related tumors mostly develop in the ascending right side of the colon (70-85%). Strikingly, it was recently discovered that dense bacterial biofilms and invasive bacteria occur in the colonic mucosa of 87% of right-sided colorectal cancer (…
To test the hypothesis that vedolizumab has chemopreventive properties with regard to colorectal neoplasia in the high-risk group of patients with PSC/IBD.