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Investigation of the signature of recurrence and radiation effects after External-Beam Radiotherapy of prostate cancer on multi-parametric MRI

Primary objective: • Investigate the signature of recurrent prostate cancer and of radiation effects after external-beam radiotherapy on multi-parametric MRISecondary objective: • Identify imaging features that are characteristic of recurrent…

Phase 2 multicenter study determining the response to Cabazitaxel in metastatic prostate cancer (mCRPC) patients with AR-V7 positive or negative circulating tumor cells (CTCs): CARVE

The primary objective of this study is to explore the PSA response rate to cabazitaxel in mCRPC patients who have progressed to docetaxel and to correlate the PSA response to AR-V7 expression in CTCs. Exploratory objectives include documenting the…

Prostate volume measurement by the general practitioner

In this research project it is investigated if abdominal ultrasound measurement of prostate volume performed by the GP is equivalent to the prostate volume measured by the transrectal ultrasound (TRUS) performed by the urologist. Also the effect on…

A pilot study to compare HistoScanning guided prostate biopsy with systematic biopsy in the detection of prostate cancer.

The primary objective of this study is to compare HistoScanningTM guided prostate biopsy with systematic biopsy in the detection of prostate cancer in men candidate for a first or second biopsy procedure.

DCE MRI in the follow-up of prostate cancer patients after radiotherapy; a matched case control stuy (Pilot)

To measure the differences of DCE MR images between patients with and without local recurrent prostate cancer in the follow up after primary treatment.

Shared care follow-up after chemotherapy for testicular cancer

The aim of this study is to develop and evaluate a shared care survivorship care plan (SCP) to follow-up patients with metastatic testicular cancer after completion of chemotherapy that resulted in complete remission.

A randomized, double-blind, placebo-controlled, multicenter Phase II trial investigating two doses of EMD 525797 in subjects with asymptomatic or mildly symptomatic metastatic castrate-resistant prostate cancer (mCRPC).

The main objective of this study is to investigate of the drug EMD 525797 is better then no treatment with subjects with metastasized asymptomatic or mild symptomatic mCRPC. The efficacy and safety of the drug EMD 525797 is evaluated.Primary…

Taste and smell changes in testicular cancer patients treated with cisplatin based chemotherapy

Primary Objective: To investigate the nature, prevalence, and duration of taste and smell changes in patients with disseminated testicular cancer treated with cisplatin based chemotherapy (BEP or EP).Secondary Objective(s): -To explore the short-…

PILOT-STUDY FOR PROFILING PSA GLYCOSYLATION AS PUTATIVE PROSTATE CANCER BIOMARKER BY HIGH RESOLUTION NATIVE MASS SPECTROMETRY

To evaluate and compare PSA-glycosylation patterns in semen of prostate cancer patients and healthy controls.To correlate PSA-glycosylation patterns in semen with pathological tumour stage and Gleason grade in prostate cancer patients.

Towards optimal treatment for high risk prostate cancer; stereotactic pelvic radiotherapy with focal boost to the primary tumor

Determine the safety (oncological outcome and toxicity) of an comprehensive treatment combining recent advances in the treatment of high risk prostate cancer.

A Phase 3 Randomized, Placebo-controlled Double-blind Study of JNJ-56021927 in Combination with Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone in Subjects with Chemotherapy-naive Metastatic Castration-resistant Prostate Cancer (mCRPC)

This study has been transitioned to CTIS with ID 2023-508606-26-00 check the CTIS register for the current data. Primary Objective:The primary objective is to compare the radiographic progression-free survival (rPFS) ofapalutamide in combination…

Health status and burden of late effects in very long-term testicular cancer survivors.

The aim of this study is to compare glomerular filtration rate (GFR) in very long-term TC-survivors treated with chemotherapy, radiotherapy or surgery only and non-cancer treated healthy controls. Furthermore, a secondary aim is to assess prevalence…

Towards optimal treatment for high risk prostate cancer; stereotactic pelvic radiotherapy with focal boost to the primary tumor

Determine the safety (oncologica! outcome and toxicity) of an comprehensive treatment combining recent advances in the treatmentof high risk prostate cancer.

DISCOVER study: Detecting Increased Susceptibility for Cancer in relatives by Offering genetic Variant Evaluation as Regular health care: prostate cancer

Mainstreaming of germline genetic tests in regular healthcare is feasible for healthcare professionals and acceptable for both patients and healthcare professionals