14 results
The primary objective of this study is to determine the anti-Xa activity after a reduced therapeutic dose of nadroparin in patients with an eGFR < 60 ml/min in comparison with the anti-Xa activity after a standard therapeutic dose of…
To assess the long-term consequences of live kidney donation, regarding kidney function, survival, hypertension, diabetes, systolic and diastolic blood pressure, mental state and quality of life.
Primary Objective: Our primary objective is to investigate the effect of NAC on H2S levels in plasma in different patient groups, i.e. healthy volunteers, CKD patients, and dialysis patients. We hypothesize that there is an increase in H2S levels…
Primary: 1 to test the safety and feasibility of autologous MSC therapy in HLA-DR mismatched patients with SCR in the renal biopsy 4 weeks after renal transplantation.Secondary1 To assess histologic changes before and after MSC treatment.2 To…
Primary objective: To assess the degree of tacrolimus over-exposure in renal transplant patients with mild diarrhea while on treatment with tacrolimus and mycophenolate mofetil.Secondary objective: To assess the intra-individual variability of…
Primary• To determine the safety profile of oral topotecan in subjects with cancer andmildly moderately or severely impaired renal function (Groups C, D and E) compared to subjects with cancerwhose renal function is normal and who have received…
1. To quantify and characterize BM progenitor cells in patients with CKD as compared to healthy controls. 2. To explore strategies to improve BM stem and progenitor cell function ex vivo.
This study assesses the effect of oral iron supplementation on gut-derived plasma uremic toxin levels in patients with chronic kidney disease (CKD) and with iron deficiency. The main research questions to be answered are:1. Does oral iron…
This study has been transitioned to CTIS with ID 2022-501677-39-00 check the CTIS register for the current data. Evaluation of patient and functional graft survival of adolescent renal allograft recipients converted from CNI to belatacept-based…
In the coming months, immunocompromised patients treated in our hospital will be requested to undergo vaccination if they comply with the National Institute for Public Health guidelines. For all subgroups, it is of utmost importance to assess the…
This study has been transitioned to CTIS with ID 2024-511810-18-00 check the CTIS register for the current data. Primary objective• To determine the 1-year graft failure-free survival in highly sensitised kidney transplant patients, pre-treated with…
This study has been transitioned to CTIS with ID 2024-515542-16-02 check the CTIS register for the current data. Primary objective:The objective is to evaluate if the LCPT dose can be reduced in comparison with tacrolimus-ER and still achieve…
The overall aim of the study is to gain more insight in as well as understand and map the pharmacokinetics of tacrolimus during pregnancy. Therefore, we will study tacrolimus concentrations in maternal whole blood (routine care) and via area under…
This study has been transitioned to CTIS with ID 2024-512544-27-00 check the CTIS register for the current data. We aim to investigate if arterial stiffness is exacerbated due to a high-salt diet in patients with ADPKD. We also intend to explore…