47 results
With this pilot study we want to see if there are measurable differences in body composition after one year. In what way does the body composition of patients change during the first year after transition from CHD to NHHD or NCHD? Is the weight gain…
Objective of this study is the development of a national "best practice guideline on pre and postnatal follow up for prenatally detected abnormalities of the kidney and/or urinary tract". Furthermore, the guidelijne will be evaluated and…
Primary objective: Is there a similar circadian rhythm of epo and melatonin in patients with the same degrees of renal insufficiency?Primary Objective: Is there a similar circadian rhythm of epo and melatonin in patients with various degree of renal…
To determine the vitamin K status in children with chronic renal failure (peritoneal dialysis patients, hemodialysis patients) and evaluate whether a correlation between bone and vascular parameters and vitamin K status exists. If vitamin K status…
Primary• To determine the safety profile of oral topotecan in subjects with cancer andmildly moderately or severely impaired renal function (Groups C, D and E) compared to subjects with cancerwhose renal function is normal and who have received…
Primary Objective: - to determine cognitive impairment in patients with severe renal failureSecondary Objective(s): - to determine to what extent this impairment improves after a kidney transplantation - to evaluate changes in uremic toxins after…
1. To quantify and characterize BM progenitor cells in patients with CKD as compared to healthy controls. 2. To explore strategies to improve BM stem and progenitor cell function ex vivo.
This study assesses the effect of oral iron supplementation on gut-derived plasma uremic toxin levels in patients with chronic kidney disease (CKD) and with iron deficiency. The main research questions to be answered are:1. Does oral iron…
2.1 Primary objectiveThe primary objective is to determine whether perirenal adipose tissue thickness is increased in patients with HFpEF compared with age, sex and BMI-matched healthy controls2.2 Secondary objectivesThe secondary objectives are to…
This study has been transitioned to CTIS with ID 2022-501677-39-00 check the CTIS register for the current data. Evaluation of patient and functional graft survival of adolescent renal allograft recipients converted from CNI to belatacept-based…
We aim to describe and identify distinct daily glucose patters (DGP) in the general population that are related to increased risk of diabetes and diabetes related micro- and macro-vascular complications using the flash sensor technology through the…
In the coming months, immunocompromised patients treated in our hospital will be requested to undergo vaccination if they comply with the National Institute for Public Health guidelines. For all subgroups, it is of utmost importance to assess the…
This study has been transitioned to CTIS with ID 2024-511810-18-00 check the CTIS register for the current data. Primary objective• To determine the 1-year graft failure-free survival in highly sensitised kidney transplant patients, pre-treated with…
Remimazolam for long-term sedation during invasive mechanical ventilation in critically ill patients
To elucidate whether a sedation regimen with remimazolam can reduce the ICU length of stay in critically ill patients with renal failure, compared to patients treated with a sedation regimen with midazolam.
Primary Objective(s) (Cohort 1):* To demonstrate that CFZ533 600 mg and/or 300 mg bi-weekly (Q2W), subcutaneous (SC), is non-inferior to a tacrolimus-based regimen with respect to the proportion of patients who experience composite efficacy failure…
This study has been transitioned to CTIS with ID 2024-515542-16-02 check the CTIS register for the current data. Primary objective:The objective is to evaluate if the LCPT dose can be reduced in comparison with tacrolimus-ER and still achieve…
To assess kidney oxygenation in obese, hyperfiltering adults with T2D before and after bariatric surgery for men and women separately determined by BOLD-MRI
The main goal of this study is to explore the pattern of physiologic and pathophysiologic cardiac recovery after a preeclamptic pregnancy compared to a normotensive pregnancy, up till 18 months PP.To study the link between placental acute atherosis…
The overall aim of the study is to gain more insight in as well as understand and map the pharmacokinetics of tacrolimus during pregnancy. Therefore, we will study tacrolimus concentrations in maternal whole blood (routine care) and via area under…
Aim of the study is to assess1) the prevalence of glomerular dysfunction and tubular dysfunction in childhood cancer survivors treated with possible nefrotoxic therapy.2) the treatment related risk factors for glomerular and/or tubular dysfunction…