35 results
To explore and optimize the usability of Doppler-OCT scanning of conditions affecting any of the retino-choroidal layers.
To detect ophthalmic differences between patients and controles. To detect (early) changes in the retina in (pre)symptomatic RVCL disease carriers, in order to find a *biomarker* for disease stage and progression.
2.1 Primary objectives2.1.1 Cross-sectional part• Technical evaluation of the functional and structural outcome measures to support a biomarker qualification by regulatory authorities and payers. 2.1.2 Longitudinal part • Assessment of prognostic…
Are changes in cognitive functioning related to structural changes in the brain in patients with type 1 diabetes mellitus. How are these changes related to diabetic complications like duration of chronic hypoglycaemia, disease duration and presence…
Assess the quality and applicability of smartphone assisted and handheld fundus photography, compared to standard fundus photography. Photographs will be taken in non-mydratic and mydriatic conditions.
Identification of the proteins that are involved in neurite outgrowth in PDR. We want to determine what protein levels are increased in the vitreous by local production and which RNA transcripts are present in the fibrotic membranes of patients with…
Both RCTs and long-term follow-up studies are required to establish optimal fetal management and provide clinicians a better understanding of the impact of these early interventions on child development in order to improve the quality of antenatal…
To detect ophthalmic differences between patients and controles. To detect (early) changes in the retina in (pre)symptomatic HCHWA-D disease carriers, in order to find a *biomarker* for disease stage and progression.
The documentation of safety and performance of silicone oil as temporary tamponade in retinal surgery.
The aim of this study is to determine whether the hydration status influences the RNFL thickness.
Primary objective: To evaluate whether patients with a prolactinoma have signs of altered vascular function and/or morphology in the retina or sublingual tissues in comparison to healthy controls. Secondary Objectives: 1. To evaluate whether there…
To perform an external (geographic and temporal) validation of predictive models for estimating the probability of PVR following primary RD using a subgroup of SNPs from a total of 197 in 30 candidate genes previously studied.
A pilot study to prove the validity of the Macubit teste, the Macuscope Test, and the measurements of the retina with the OCT, to test for early functional, and structural loss in the central part of the macula in patients at risk for developing…
Evaluation of the hypothesis that outcomes of Dermabond tissue adhesive and conventional suturing for securing episcleral explant in retinal detachment surgery are equivalent.
1) To demonstrate that the FcRn functions as a transporter and protector for vitreous IgG and monoclonals (Avastin, Lucentis) and show that monoclonal therapeutic antibodies are transported over the RPE via the FcRn. 2) To investigate if…
To improve imaging of sub-RPE structures with OCT.
1.To investigate the relationship between amblyopia and the development of the neurosensory retina:Measurements: Central / foveal retinal thickness RNFL Inner retinal layer thickness thru segmentation algorithms 2.To investigate the differences in…
To compare the severity of retinopathy of prematurity (ROP) among treated infants with an untreated control population, matched for GA at birth while confirming the dose of rhIGF 1/rhIGFBP-3 is safe and efficacious.
The key objectives of this study are to identify both the genetic background and pathophysiological mechanisms that underlie CSC. To achieve this we will: 1) Perform genetic analysis and ophthalmological examination in a cohort of sporadic CSC…
The objective of this study is to analyse the retinal oxygenation in adults with the Oxymap T1 in patients with amblyopia and untreated or treated (vitreo-) retinopathies and compare them to a reference group of healthy eyes of amblyopic and Coats…