15 results
To detect ophthalmic differences between patients and controles. To detect (early) changes in the retina in (pre)symptomatic RVCL disease carriers, in order to find a *biomarker* for disease stage and progression.
Identification of the proteins that are involved in neurite outgrowth in PDR. We want to determine what protein levels are increased in the vitreous by local production and which RNA transcripts are present in the fibrotic membranes of patients with…
To perform an external (geographic and temporal) validation of predictive models for estimating the probability of PVR following primary RD using a subgroup of SNPs from a total of 197 in 30 candidate genes previously studied.
1) To demonstrate that the FcRn functions as a transporter and protector for vitreous IgG and monoclonals (Avastin, Lucentis) and show that monoclonal therapeutic antibodies are transported over the RPE via the FcRn. 2) To investigate if…
The key objectives of this study are to identify both the genetic background and pathophysiological mechanisms that underlie CSC. To achieve this we will: 1) Perform genetic analysis and ophthalmological examination in a cohort of sporadic CSC…
The objective of this study is to analyse the retinal oxygenation in adults with the Oxymap T1 in patients with amblyopia and untreated or treated (vitreo-) retinopathies and compare them to a reference group of healthy eyes of amblyopic and Coats…
The objective of this study is to investigate the use of retinal oximetry in children, between five and seventeen years of age, with (vitreo-) retinopathies and oxygen-related diseases of the retina by means of an Oxymap T1 fundus camera.
To study the efficiency of visual information processing in patients with retinal disorders.
Development of a laboratory assay
To demonstrate that cone density can be reliably and accurately measured after vitrectomy for RRD split fovea and for RRD macula-off.
To determine whether functional and/or structural retinal biomarkers or circulating biomarkers can be used to determine the speed of cognitive decline in people with T2D and MCI and those at higher risk of developing dementia.
The aim of this research is to study several important biomarkers of patients with diabetic macular edema and exsudative macular degeneration. Biomarkers are biological characteristics in the body (such as substances, structures and processes) that…
The main objective of this study is to compare calcification promoting and inhibiting factors and their interactions in the serum of PXE patients and healthy controls. Secondary objectives (optional) are:1) to identify differences in cognitive…
Dissection of etiology of myopia- identification of genetic risk factors- identification of environmental risk factors- evaluation of the long term safety of Artisan phakic intraocular lenses for the correction of high degree myopia
To demonstrate whether a statistically significant difference exists between T2D patients with and without DR.