80 results
Primary research questionDo obese PCOS women with reduced insulin sensitivity have HDL particles that have impaired anti-oxidative function in comparison with lean controls with normal insulin sensitivity?Secondary research questionDo obese PCOS…
The purpose of this study is to investigate whether the hyperactive pelvic floor syndrome can be assessed by objective measurement. This will be done by means of a newly developed instrument, the so-called VPA/EMG/sensibility-combiprobe, that…
Primary Objective: To identify maternal and embryonic factors associated with recurrent implantation failure, by prospectively• comparing embryo and endometrium secretion cytokine profiles of women with recurrent implantation failure versus women…
Main: Investigate the cyclic variation in clot lysis time in women with HMB in comparison to controls. Secondary:- Investigate the cyclic variation in TAFI, PAI-1, tPA, PI, thrombin generation, fibrinogen, fibrin clot permeability and confocal…
The aim of this pilot study is validate the multiplex PCR for bacterial vaginosis and candidiasis on the basis of Nugent score, Amsel criteria, clinical diagnosis of candidiasis and culture before and after treatment. Besides that we will measure…
The aim of this study is to investigate the structure and the biological behaviour of the peritoneum, in relation to the specific growth of EOC on the peritoneum, in order to identify the component of the peritoneum that maintains the blood-belly-…
The objective of the study is the falsification of the following null hypotheses:1. The pro-inflammatory status of the innate immune system of normal fertile women and the of women with idiopatic subfertility are not different.2. The profile of the…
The objective of this study is to investigate the intra-individual change in AMH levels over several years in female RA patients.
To demonstrate the presence of a reduced age specific ovarian reserve status in BRCA mutation carriers by:1. using serum AMH as ovarian reserve status test. 2. using the antral follicle count (AFC) as ovarian reserve test3. using ovarian response to…
This study is to answer two questions. First the reliability and validity of the novel lavage method to screen on cervical cancer in combination with the clinically validated hrHPV and hypermethylation triage tests. Second the functionality and…
Primary Objective: To study long-term effects of premenopausal risk-reducing salpingo-oophorectomy (RRSO) on - cardiovascular status- bone mineral density- cognitionSecondary Objective: To study long-term effects of premenopausal RRSO on - quality…
This DCOG-LATER project proposal aims to characterize the overall, disease and treatment-related risks of sexual dysfunction and delays in psychosexual development in a Dutch cohort of 5-year CCS treated in the period 1960-2001 and to evaluate the…
The aim of this research is to test the efficacy and safety of a new microcatheter 2.8F Sequre for treatment of uterine fibroids and/or adenomyosis with a standard embolization technique and to demonstrate the added value of this catheter, namely to…
The aim of this pilot study is to determine the diagnostic value of exhaled breath analysis by eNose technology for endometriosis patients: does it detect endometriosis?
To evaluate whether a less radical surgical approach with sentinel lymph node biopsy is non-inferior to treatment with systematic pelvic lymphadenectomy.The null hypothesis is that the recurrence rate after SLN biopsy is non-inferior to the…
1. To study the possibility to detect gynaecological malignancies and endometriosis in Pap smears and blood of women with gynaecological cancer or endometriosis, using MeD-seq and biomarker assays, in order to develop new reliable screening methods…
This study aims to investigate the progression-free survival (PFS) according to RECIST 1.1 criteria on matched targeted therapy by STA-analysis (PFS2) in comparison to the PFS recorded on the therapy administered immediately prior to enrolment (PFS1…
To study the value of mpMRI with subsequent targeted biopsies after inclusion to more accurately grade prostate cancers of men on active surveillance. Furthermore, the value of mpMRI in reducing the number and amount of biopsies will be studied.
To investigate the influence of aprepitant on the exposure to etoposide in TC patients treated with (B)EP.
The aim of this study is to assess the relationship between the AGD, the 2D:4D ratio and the presence of MRKH syndrome, endometriosis and PCOS.