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Molecular studies on reduced ovarian reserve and embryo competence in BRCA1/2 mutation carriers

Investigate the association between BRCA1/2-mutations, DNA damage, apoptosis and oocyte/embryo quality in immature germinal vesicle (GV) bearing oocytes, immature metaphase 1 (MI) and unfertilized mature metaphase 2 (MII) oocytes and affected early-…

Unravelling brain mechanisms of cognitive impairment in breast cancer patients during adjuvant endocrine treatment

Primary Objective: Does long-term endocrine adjuvant treatment for breast cancer lead to structural changes in the brain and to functional changes in brain-wide networks, and do these changes correlate with cognitive impairment induced by the…

The TESTBREAST study: early detection of breast cancer in women at high risk of developing breast cancer with serum biomarkers.

Early detecction of breast cancer in women with high risk of developing breast cancer with protein and glycan biomarkers.

The Utrecht cohort for Multiple BREast cancer intervention studies and Long-term evaLuAtion

To set up a cohort of breast cancer patients, collecting information on patient characteristics, short and long-term clinical and patient reported data, and to compare outcomes with a healthy refrence population. whichThe cohort will also serve as…

The effect of Hyperbaric OxygeN therapy on brEast cancer patients with late radiation toxicitY

To assess whether HBOT reduces pain, and improves physical functioning and QoL in breast cancer patients with late radiation toxicity.