760 results
We want to gain more fundament insight in disturbed sensorimotor integration in PD, particularly with regard to the impact of visual stimuli on the cerebral organization underlying gait control. Such knowledge provides arguments for targeted patient…
The primary objective of this study is to detect statistically significant differences between the most severely affected PD subtype and controls on 3T imaging parameters.
In this study we want to investigate if relaxation time (RT) measured by handgrip myometry and muscle- elastography is a reliable outcome measurement for the quantification of myotonia in NDM patients. Mean RT values en standard deviations of NDM…
In this research, a small group of children known to suffer from complex febrile seizures (FS) will be studied. An increase in expression of FS1 will be investigated in blood in comparison with an control group. This will be done by isolating FS1…
Discrimination of probable AD patients from healthy volunteers by ZK 6032924 PET imaging as evaluated by visual analysis of the brain distribution patterns and by SUV values in probable AD patients as compared to healthy volunteers for brain imaging…
Primary objective of the study:To find out which areas in the brain play a part in the maintenance of tinnitus, and what the roles of those areas are. This will be done using the AEP response in EEG recordings.Secundary objectives of the study:1. To…
Objectivesi)) To study whether reproductive hormones play a role in migraine susceptibility in malemigraine patients; ii) to study functionality of the trigeminal system prospectively duringinterictal and premonitory phases of the migraine attack (…
The purpose of this research project is to assess whether affected PKD patients have brain abnormalities compared to healthy normal controls. Hypothesis: Paroxysmal kinesigenic dyskinesia affected individuals exhibit abnormal spontaneous activity of…
Does mitochondrial dysfunction play an important role in the pathofysiology of patients with Complex Regional Pain Syndrome Type I ?
2.1 Primary Objectives: 1) To test the feasibility of the six minute assisted leg and arm cycling test in patients aged 6-18 years with Duchenne muscular dystrophy (DMD), Beckers muscular dystrophy (BMD), Limb Girdle muscular dystrophy (LGMD),…
The purpose of this study is the expansion of the conventional MRI sequences for the diagnosis for patients with probable dementia. The focus is on structural imaging, anatomical and functional connectivity. Patterns of change in brain connectivity…
To examine neurocognition in 100 HIV1 seropositive patients on chronic effective cART using three different tests: the Montreal cognitive assessment (MoCA) , the International Aids Dementia scale (ADS) and extensive neuropsychological testing of…
We aim to determine onset of SCA6 disease more accurate then with the clinical scores and questionnaires that are currently used. We will study motor performance, motor learning behavior, PPI and MRI scans in pre-symptomatic SCA6 patients and…
The purpose of this study is aimed at the effects of early discharge from a hospital followed by adequate rehabilitation planning in a nursing home. It concerns a (cost)effective evaluation of a renewed stroke care model that was implemented in 2006…
Key hypothesis of the investigation is that Parkinson*s disease is characterized by deficient entrainment of slow brain oscillations. Our previous work already provides preliminary support for this hypothesis. In order to evaluate to what extent…
Primary Objectives• To evaluate the analgesic efficacy of JNJ-42160443 (1, 3, and 10 mg; administered as a single, subcutaneous injection every 28 days) in reducing average pain intensity, in subjects with postherpetic neuralgia neuralgia • To…
We aim to establish whether our judgment of *misperception* is really doing justice to the condition paradoxical insomniacs suffer from. We should keep in mind that our present definition of sleep, based on the standardized polysomnographic scoring…
Primary: Does immunomodulation brought about by interferon beta-1a (Rebif) enhance or prolong functional reorganization in subjects with RRMS?Secondary: Does interferon beta-1a (Rebif) also affects functional connectivity as measured by resting-…
Primary objective: To set up a repository of genetic material from a large group of well phenotyped people with epilepsy patients to allow the case control association studies, to analyze and detect genetic risk factors for epilepsy. Secondary…
The goals of the present study, therefore, are twofold:a) To estimate the incidence of dream/reality confusions in the narcoleptic population, relative to healthy controlsb) To provide a comprehensive description of the characteristics of these…