24 results
We aim to extend our recent work on fundamental mechanisms that underlie automatic influences of reward on attention to clinical populations that suffer from reduced and excessive reward-driven behaviours. That is, we will investigate whether…
The main objective of this study is to characterize the features and the extent of extracerebellar structural pathology in SCA3 and SCA6 patients. Secondary objectives are:- To explore the sensitivity of DWI and other imaging modalities in detecting…
1. We will recruit 6 probands who experience cerebellar movement disorders with spinocerebellar ataxia features such as uncoordinated movement (i.e. asthenia, asynergy, delayed reaction time and dyschronometria) in limbs and organs such as the eyes…
Obtaining fundamental insight into sensorimotor integration in Parkinson's disease, targeted on (i) the relationship between cognitive deficits and prosodic anomalies, and (ii) the effect of music on the motor aspects of speech production.
We want to gain more fundament insight in disturbed sensorimotor integration in PD, particularly with regard to the impact of visual stimuli on the cerebral organization underlying gait control. Such knowledge provides arguments for targeted patient…
The primary objective of this study is to detect statistically significant differences between the most severely affected PD subtype and controls on 3T imaging parameters.
The main objective of this study is to detect potential biomarkers for the differentiation of PD and DLB and the differentiation of PD subtypes by using neuroimaging.
The objective of this study is to provide a reliable overview of the oral health of Parkinson's disease patients in the Netherlands.
The main goal of this study is to investigate the influence of STN DBS on the cognitive processes of reward processing and selective visual attention.
This project has three separate but complementary research objectives. First, to find out whether there is indeed evidence of subclinical cerebellar dysfunction in these subjects, by specifically focusing on cerebellar motor learning. Second, to…
The aim of this study is to gain understanding of the functioning of spinal reflexes in patients with MD, using a new method involving EMG, EEG and the wrist manipulator.
Primary Objective: To determine the characteristics of the short-latency muscle response (SLR) in patients with Parkinson*s disease, in comparison to age-matched healthy controls.Secondary Objective(s): To correlate the characteristics of the SLR…
Primary Objectives* To investigate the intra-variability (day-to-day) of glucocerebrosidase pathway biomarkers in HV, PD-GBA+ and PD-GBA-Secondary Objectives* To investigate the intra-variability (within-day) of glucocerebrosidase pathway biomarkers…
To set up a trial*ready cohort by bringing together 7 European cohorts and 1 US cohortand include new subjects, which together comprise more than 800 subjects with the developmentand validation of innovative assessment instruments and disease…
Primary Objective: • To chart longitudinal disease progression rates for SPG7 and ARSACS by a multisite, prospective natural history study. Secondary Objective(s): • Development of a new clinical SPAX composite scale.• To identify (a combined set of…
Primary Objective- To identify (a combined set of) clinical and non-clinical markers most sensitive to disease progression in Dutch SCA1 mutation carriers. Secondary Objectives:- To quantify the annual change in disease-relevant clinical scales and…
Our primary objective is to compare neuroimaging markers on a 3T MRI-scan with the MRI-scans that were performed during TRACK-HD in 2008-2011. We will assess the following neuroimaging markers, starting with the most important marker: 1. Structural…
Primary objective: To evaluate the role of existing and novel quantitative biomarkers in understanding the heterogeneity in the Parkinson*s phenotype (i.e. rate of progression, cognitive and neuropsychiatric impairment and motor dysfunction) and…
Primary objective:- To identify (a combined set of) clinical and non-clinical markers most sensitive to disease progression in Dtuch SCA7 mutation carriers.Secondary objectives:- To quantify the annual change in disease-relevant clinical scales and…
Our primary objectives are to study: 1) differences in the brain*s sensitivity to the effects of light on emotional processing in people with PD and people with depressive symptoms compared with healthy controls 2) whether different spectrum of…