10 results
The goal of the project is to validate the developed standardized atrophy measurement method at VU University Medical Centre in patients with MS. This is done by testing how well the measurements of atrophy agree between different scanners and…
a) To study the relationship between ankle push off and walking-induced motor fatigability and the potential confounders of this relationship in persons with progressive MS and healthy controls. b) To assess the feasibility of a targeted, sequential…
Our primary objective is to identify de novo/rare mutations causative of MS using WES in members of multi-incident families. Our secondary objective is to describe phenotypes per family using questionnaires and semi-structured interviews with family…
To investigate the impact of high field 3T MRI on the diagnostic criteria in MS in a large multicenter study population using multiple vendor MRI systems.
The aim of this MRI study is to understand how neurodegeneration in MS (in vivo) is related to other facets of MS pathology, i.e. inflammatory (T2) lesions, black hole (T1) lesions, cortical lesions and damage of the normal appearing brain tissue.…
The main point of this study is to detect in a controlled fashion if there is a relationship between CCSVI and MS. We focus on 5 parameters indicative of CCSVI: 1-reflux in the internal jugular vein (IJV) or in the vertebral vein (VV), or both with…
This study aims at investigating in vivo the macroscopic and microscopic aspects of brain and cervical cord neuroaxonal pathology in multiple sclerosis in a cohort of PPMS patients, by measuring brain and cervical cord atrophy, the ratio of N-…
In our longitudinal study we would like to investigate whether measures of neuronal damage, glial damage and oxidative stress are correlated with the speed of progression of disability. We would also like to investigate whether these variables…
This pilot study aims to explore whether and why the cardiorespiratory fitness is compromised in newly diagnosed patients with early Relapsing Remitting Multiple Sclerosis (RRMS) with no or minimal clinical symptoms (i.e. Expanded Disability Status…
To assess activated microglia in vivo in clinically and/or radiologically active RRMS patients compared to healthy controls using the PET-tracer [11C]SMW139, to assess retest variability in regional [11C]SMW139 brain uptake, and to evaluate which…