15 results
PROUD is a multicentre prospective study, using clinical factors in combination with additional tests with the aim to clarify more about the aetiology and pathogenesis of MS.
To identify (clinical) features of MMN patients that predict a poor clinical disease course. Moge agressive IVIg regimen can be established is this subgroup to maintain functional status of the patient. To find domains in quality of life in MMN…
To determine whether damage in the cortical and/or subcortical GM in patients with early RRMS increases in regions connected to more damaged WM tracts, i.e. WM tracts with larger lesion volume, WM tracts with more severe damage inside lesions, and/…
(1) to establish the neuropsychiatric and personality status (symptoms and impairments) (2) to assess the possible determinants of these symptoms and impairments and (3) to examine the impact of these symptoms and impairments on daily life…
The primary objective of this study is to determine the prevalence and degree of impaired cerebral venous drainage in MS patients in comparison to healthy subjects.Secondly, we want to determine a possible relationship between the degree of impaired…
Isolation of skin fibroblasts from MS patients for reprogramming into induced pluripotent stem cells
In this study we aim to address the hypothesis that oligodendrocytes and oligodendrocyte precursor cells from MS patients exhibit epigenetically determined differences in protein expression profiles and functional behavior in comparison to those…
The aim of the proposed study is to get more insight into the role of the hippocampus and thalamus in cognitive impairment in MS patients. To achieve our goal, we propose to study the (abnormal) structure and function of the two structures with…
In this study we would like to investigate whether cerebral perfusie and cerebral metabolism can be influenced with pharmacological agents in patients with MS and in healthy control persons. Cerebral perfusion and cerebral metabolism wil be measured…
The main objective of this project is to identify the early brain changes in MS (i.e. patients that are recently diagnosed with MS) that can be measured by advanced structural and functional (network) imaging measures. Additionally, we will…
The PROUD-kids 2.0 study aims to find parameters to identify and distinguish between the different subtypes of ADS. Also finding predictive factors for disease course and disease severity. Genetic and environmental factors will be investigated to…
To identify prognostic factors for disease course and severity, as soluble and cellular biomarkers, immunological, genetic, radiological and demographics factors.
The main objective of this project is to build a comprehensive model for a better predictio n of progression in MS, as a first step to move towards personalized prediction. Secondary objectives aim to study specific aspects of underlying mechanisms…
In the current *proof of principle* study, it is hypothesized that ex vivo expansion of Tregs originating from patients with the prototypic examples from the spectrum of autoimmune or inflammatory diseases (SLE, AAV, MS or CD) can be accomplished by…
The aim of the present study is to examine whether MS patients report a significant higher amount of behavioural problems compared to the normal population and another patient group diagnosed with a non CNS-involved chronic disease (patients with…
To identify determinants that explain phenotypic variability in MS while excluding age as a confounding factor and to detect determinants which may guide intervention strategies and predict the disease course in MS.