46 results
In the proposed experiments we intend to investigate both central and peripheral aspects of fatigue in MS patients using a combination of simultaneously applied techniques; twitch-superimposition, electromyographic (EMG) and force recordings and…
This study aims at investigating in vivo the macroscopic and microscopic aspects of brain and cervical cord neuroaxonal pathology in multiple sclerosis in a cohort of PPMS patients, by measuring brain and cervical cord atrophy, the ratio of N-…
In this study we would like to investigate whether cerebral perfusie and cerebral metabolism can be influenced with pharmacological agents in patients with MS and in healthy control persons. Cerebral perfusion and cerebral metabolism wil be measured…
In our longitudinal study we would like to investigate whether measures of neuronal damage, glial damage and oxidative stress are correlated with the speed of progression of disability. We would also like to investigate whether these variables…
How important is fatigue in patients with MTBI? What are the mechanisms underlying the decline in force during a fatiguing task? Which changes in brain activation take place during the fatiguing task?
We aim to determine the difference in uni- and bimanual coordination between young adults, older adults and MS patients. Additionally we want to determine the relation between the different measures of cortical inhibition and task performance.
Primary objectiveTo assess the safety and tolerability after single and multiple intravenous administrations of PPSGG in patients suffering from anti-MAG neuropathy.Secondary objectives- To evaluate the PK of PPSGG after single and multiple…
This pilot study aims to explore whether and why the cardiorespiratory fitness is compromised in newly diagnosed patients with early Relapsing Remitting Multiple Sclerosis (RRMS) with no or minimal clinical symptoms (i.e. Expanded Disability Status…
The main objective of this project is to identify the early brain changes in MS (i.e. patients that are recently diagnosed with MS) that can be measured by advanced structural and functional (network) imaging measures. Additionally, we will…
The purpose of this study is to assess the feasibility of decoding multiple movements from sensorimotor cortex of people with late-stage ALS and healthy controls.
The primary objective of the study is to investigate changes in white matter structural integrity in patients with relapsing remitting multiple sclerosis (MS) after treatment with dimethyl fumarate and its relation to physical and cognitive…
The PROUD-kids 2.0 study aims to find parameters to identify and distinguish between the different subtypes of ADS. Also finding predictive factors for disease course and disease severity. Genetic and environmental factors will be investigated to…
To identify prognostic factors for disease course and severity, as soluble and cellular biomarkers, immunological, genetic, radiological and demographics factors.
This study has been transitioned to CTIS with ID 2024-513105-31-00 check the CTIS register for the current data. Primary Objective: Our objective is to validate the safety, measured by radiological disease activity, of personalized extended interval…
To describe the efficacy and safety of a maintenance versus induction anti-CD20 treatment strategy in pwMS.
The main objective of this project is to validate a standardized volume measurement system (using eight in-house 3D printed phantoms) to allow for reliable atrophy measurements in MS, by quantifying between-scanner and within-scanner reproducibility…
To assess the efficacy of add-on high-dose simvastatin on markers for disease progression in MS patients treated with natalizumab or ocrelizumab for at least six months.
In the current *proof of principle* study, it is hypothesized that ex vivo expansion of Tregs originating from patients with the prototypic examples from the spectrum of autoimmune or inflammatory diseases (SLE, AAV, MS or CD) can be accomplished by…
• 1A: Does aging have additional effects on motor performance in persons with MS compared to age- and sex matched controls?• 1B: Does aging have additional effects on fatigue and fatigability in persons with MS compared to age- and sex matched…
The primary objective of this pilot study is therefore to investigate the effects of TENS on brain activity in pwMS measured with fMRI.