52 results
Our overall aim is to obtain a better understanding of brain network damage in dementia patients. We propose a research project with two key objectives:1. Develop improved methods to describe functional brain network damage2. Relate network damage…
The goal of PCI is to increase the neurological disease-free survival, without significant side effects, and hence to improve HRQOL. This sub-study aims to investigate this expected advantage of PCI in NSCLC in maintaining function and increasing…
Our working hypothesis is based on the interplay between vascular dysregulation, neuropathological alterations and decline in AD brain function. In the latent phase vascular dysregulation is already apparent when patients are asymptomatic.…
Primary:1. Which outcome variables of oculomotor performance and eye-hand coordinatio are useful to distinguish between Dementia with Lewy bodies, Alzheimerdementia and Parkinsondementia.Secundary:1. What are the base line values for the parameters…
The objective of this study is to proof the presence of lesions in the brain of patients with overactive bladder and urge-incontinence (OAB wet) as a central cause of this disorder. This survey is a pilot investigation for a larger study on the…
The primary aim of the proposed multi-site study will be to determine internal and external validity of the proposed new diagnostic criteria.
The main aim of the study is therefore to examine mu wave activity during observation, execution of movements and during movement imagery in comparison to a passive resting state and active relaxation condition in stroke patients and matched healthy…
Primary objective: the primary objective of the present study is to assess whether apathy can be linked to structural brain changes (both atrophy of grey matter, as well as changes in white matter), whether apathy in PD is related to certain…
The Sport-2-Stay-Fit (S2SF) Study will investigate if an after school sports program increase the sustainability of a standardized interval training program in children and adolescents with a physical disability or chronic disease.
This pilot study aims to investigate the retina, macula and optic nerve head with Optical Coherence Tomography (OCT) in AD patients in order to identify a neurodegenerative signature of AD in the eye. With Fundus Autofluorescence (FAF), amyloid…
Part 1: To evaluate the effects of BIIB033 versus placebo on disability improvement over 72 weeks.Part 2: evaluate long-term safety profile of BIIB033 as an add-on therapy in subjects with MS.
Exploration and possibly chaniging of the VBMEG method to analyse dynamic changes in the connectivity network in epilepsy patients. This study is a prerequisite to apply the VBMEG method to a larger dataset to possibly identify a quantitative…
Our objective is to find predictive biomarkers for disease progression in RVCL-S, a monogenetic small vessel disease, and to dissect disease mechanism to identify new treatment targets to improve health for RVCL-S patients, which may also serve as…
In this study we will investigate how safe the new compound MT1980 is and how well it is tolerated when it is used by healthy participants. We also investigate how quickly and to what extent MT1980 is absorbed, transported, and eliminated from the…
The objectives of this study are to:• Assess safety and tolerability of imlifidase in combination with standard IVIg treatment in GBS subjects• Evaluate pharmacokinetics of imlifidase• Evaluate pharmacodynamics profile of imlifidase• Evaluate…
Here we will test the hypothesis that tACS (theta-tACS at 6 Hz) will enhance brain synchrony in MS patients, thereby improving their cognitive functioning. We further want to achieve the increase in fronto-temporal brain synchronization measured by…
The main objective of the study is to investigate MEG-based hippocampal and whole brain neuronal hyperactivity in preclinical DIAD mutation carriers and to find proof-of-concept for the translatability of findings from preclinical AD mouse models to…
This study has been transitioned to CTIS with ID 2023-506516-40-00 check the CTIS register for the current data. The primary efficacy objective for this study is to demonstrate non-inferiority of ocrelizumab compared with fingolimod
1. To quantify brain iron accumulation in patient with HD using quantitative susceptibility mapping (QSM) at ultrahigh field (7T) as compared to healthy controls (case-control design).2. To link QSM results with specific and well-known clinical CSF…
The overarching aim of this study is to develop new, sensitive measures for aspects of social cognition (emotion experience, empathy and affective theory of mind), that will contribute to a better and earlier diagnosis of specific subtypes (the…