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Interbody fusion in the treatment of cervicobrachial syndrome; a prospective trial of porous titanium cervical cages.

Documentation of the patients' functional recovery and quantification of fusion after implantation of 3-D trabecular titanium cages on the short and long term. These data will be compared with the recently performed randomized CASCADE trial on…

New training modules aimed at improving upper extremity skilled performance in persons with a cervical spinal cord injury

The aim of the study is to develop and evaluate a specific client centred task-oriented training module for upper extremity skilled performance in persons with C-SCI.The research questions are:1. Does an 8-weeks client-centred task-oriented training…

Multiple dose safety, tolerability, plasma and cerebrospinal-fluid pharmacokinetic study of oral doses of CORT113176

In this study we will investigate how safe the new compound CORT113176 is and how well it is tolerated when it is used by healthy participants.We also investigate how quickly and to what extent CORT113176 is absorbed, transported, eliminated from…

A Phase 2a Study of TPN-101 in Patients with C9ORF72 ALS/FTD (Amyotrophic Lateral Sclerosis and/or Frontotemporal Dementia)

The primary objective of this study is:* To assess the safety and tolerability of TPN-101 in patients with C9ORF72 ALS/FTDThe exploratory objectives of this study are:* To assess the concentrations of TPN-101 in plasma and cerebrospinal fluid (CSF…

Clinical assessment of upper extremity performance in individuals with spinal cord injury using the LIFT System to deliver non-invasive electrical spinal stimulation (ARC Therapy)

Safety: To provide confirmatory evidence that use of the LIFT System, inclusive of all components and accessories, is safe.Effectiveness: To provide confirmatory evidence that use of the LIFT System provides an effective treatment for the…

Handheld iOS-based spinal navigation versus computer tomography-based image guided navigation in the placement of thoracolumbar pedicle screws; protocol of a randomized controlled trial

The aim of the study is to determine the accuracy of pedicle screw placement when using the iNav navigation tool compared with the established computertomography based navigation.

Coping and living with chronic pain in persons with spinal cord injury: daily life participation and quality of life.

To design and test a personalized biopsychosocial rehabilitation treatment that aims to restore daily life functioning and QoL in persons with SCI and chronic pain.

(Cost)effectiveness of a personalized multimodal physical therapy program compared to surgery in patients with cervical radiculopathy: a randomized non-inferiority trial

To investigate if a personalized multimodal physical therapy program compared to ACDF surgical treatment is non-inferior over a 12-month period and cost-effective in patients with painful cervical radiculopathy who have an indication for…

Interbody fusion in the treatment of cervicobrachial syndrome; a prospective 5-year follow up extension study of porous titanium cervical cages

Evaluation of longterm clinical and radiological results.

Effectiveness of surgery versus prolonged conservative care in patients suffering from a herniated cervical disc

It is required to compare results from conservative- and surgical treatment in The Netherlands and to perform an economic evaluation in order to evaluate the cost-effectivity of both treatment types. On one hand, surgical treatment seems accompanied…