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(Cost)effectiveness of a personalized multimodal physical therapy program compared to surgery in patients with cervical radiculopathy: a randomized non-inferiority trial

To investigate if a personalized multimodal physical therapy program compared to ACDF surgical treatment is non-inferior over a 12-month period and cost-effective in patients with painful cervical radiculopathy who have an indication for…

*A prospective randomized multicenter study to demonstrate the superiority of the Barricaid® to discectomy for primary lumbar disc herniation*: Extended Follow-Up of the Barricaid® Annular Closure Device (ACD) Randomized Control Trial (RCT) Postmarket Cohort for Lumbar Disc Herniation and Interaction with Other Risk Factors

The purpose of this post-approval protocol amendment is to extend the follow-up of subjects who were originally enrolled in theRCT, EUBARD-CP_001 protocol. This study extension will examine the long-term survivorship of the Barricaid® ACD when…

Characterisation of the immune response after spinal cord injury

This project focuses on the characterization of the immune response following a traumatic SCI. As individual components of the immune response work in close collaboration and have a strong influence on each other, it is important to obtain a very…

Quantifying disease progression in LBSL

Objective: The primary objective of this proposal is to develop new sensitive and quantitative outcome measures for clinical trials in LBSL. The secondary objective is to identify biomarkers to stratify patients based on disease progression rate.

Evaluation of smoking cessation on the clinical and radiological outcome of instrumented neck- and low back surgery

Objective: To demonstrate that smoking cessation in the postoperative period has a positive impact on the clinical and radiological outcomes of instrumented spine surgery

The role of the relative aerobic load of walking and walking behaviour after spinal cord injury

The primary aim is to determine whether the relative aerobic load of walking is a determinant of the amount of walking in daily life in people with a chronic spinal cord injury with a walking function. Secondary goals are to gain insight into other…

Interbody fusion in the treatment of cervicobrachial syndrome; a prospective 5-year follow up extension study of porous titanium cervical cages

Evaluation of longterm clinical and radiological results.

Central sensitisation in patients with chronic low back pain radiating to the leg

To determine the presence or absence of central sensitisation in patients with CLBPr and to determine the effect of segmental nerve interventions on central sensitisation.

Detection of circulating tumour cells in cerebrospinal fluid (CSFCTs) to diagnose leptomeningeal metastases (LM) among breast cancer patients

In this pilot, we aim to improve the detection rate of LM by using the CellSearch technique quantifying circulating tumor cells (CTCs) in cerebrospinal fluid (CSF, i.e. CSFCTs) and compare this with the current standard of care; namely cytological…

Wheels lifestyle intervention study.

Primary objective:Does the use of the application support a positive lifestyle development?Secondary objectives:Does the use of the application support an increase in physical activity levels?Does the use of the application has a positive influence…

Effectiveness of surgery versus prolonged conservative care in patients suffering from a herniated cervical disc

It is required to compare results from conservative- and surgical treatment in The Netherlands and to perform an economic evaluation in order to evaluate the cost-effectivity of both treatment types. On one hand, surgical treatment seems accompanied…