61 results
To report on (the age-dependency of) the long-term effect(s) of chronic SSRI treatment during adolescence or adulthood on the outgrowth and function of the 5-HT system, using state-of-the-art Magnetic Resonance Imaging (MRI) techniques and other,…
The primary objectives are defined according to a hierarchical design: i) to tailor and apply multi-parametric, functional MRI techniques to identify cerebral abnormalities (cerebral biomarkers) in DM2 and MetS; ii) to investigate which cerebral…
Addictive disorders affect a steady proportion of the population, and result in significant negative personal consequences(e.g. loss of jobs, psychosocial problems) and costs to society (absence from work due to hangover, treatment costs).GHB is…
The current study will focus on the effects of an intensive programme of exposure of prism adaptation (i.e. daily exposure during two weeks) and compare these to sham adaptation.
The primary objective of this study is to evaluate neurophysiologic changes of the pain centres of the brain (the differences in particular in the thalamus, primary and secondary somatosensory cortex, insula, anterior cingulate cortex and the motor…
The main goal of the study is to develop and validate a device that provides an objective measure of degradation of motor performance in elderly people. The device will assist to diagnose neurodegenerative disorders in the elderly at an early stage…
The primary aim is to investigate the effects of attentional focus manipulation on the performance of a repetitive leg movement task under single and dual-task conditions in ABI patients. Furthermore, it will be investigated to what extent the…
Primary Objective: Our main goal is to contribute to the identification of an attentional profile of the paediatric TBI population, by analysing the quality and efficiency of alerting, orienting, executive and sustained attentional functioning. This…
With this research we intend to fill the gap described in the previous chapter by:1) Detecting functional network changes in several causes of early-onset dementia and to characterize the specific changes for each dementia cause.2) Relating specific…
Primary objective of the study: 1. To report on the age-dependency of the effect(s) of MPH or SSRI treatment on the outgrowth of the DA and 5-HT systems, respectively, using state-of-the-art Magnetic Resonance Imaging (MRI) techniques
Primary objective: The ultimate goal is to achieve a more sensitive method for detecting malformations of cortical development. This encompasses two steps: the development of the method and the assessment of the sensitivity and specificity of the…
The purpose of this study is the expansion of the conventional MRI sequences for the diagnosis for patients with probable dementia. The focus is on structural imaging, anatomical and functional connectivity. Patterns of change in brain connectivity…
The purpose of this research line is to assess whether measures acquired with advanced MR neuroimaging can be used as neuropathological markers for the early diagnosis of dementia and differentiation between AD and FTD. For each project, the…
Addictive disorders affect a steady proportion of the population, and result in significant negative personal consequences (e.g. loss of jobs, psychosocial problems) and costs to society (absence from work due to hangover, treatment costs). GHB is…
The main, primary objective of this study is identification of the molecular mechanisms that regulate structure and function of red blood cells in patients with neurodegeneration accompanied by the presence of abnormal red blood cells (…
Primary Objective: To examine which subregions of the hippocampal formation on 7 Tesla MRI are most affected in patients with early Alzheimer*s disease compared with older persons with normal cognition. Secondary Objectives:a) To explore risk…
In this study, we will systematically investigate the influence of distractors on target processing in patients with lesions to the frontal, parietal and occipital system. This will be measured by eye movements. Furthermore, prism adaptation will be…
The first line of research encompasses the frequency, severity, and (dis)similarities of perceptual and attentional impairments in near and far space. Differential impairments of near and far space processing are more likely to be found when spatial…
To examine whether it is possible to combine the sensitivity of neuropsychological tasks with the efficiency of brief cognitive instruments.
The primary objective of the study is to examine the feasibility of measurements, program design and implementation adherence of a cardiovascular exercise program in persons with Down*s syndrome suffering from Alzheimer*s disease. Secondary…