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Long-term effects of SSRI treatment during (late) brain development in OCD patients: a retrospective MRI study.

To report on (the age-dependency of) the long-term effect(s) of chronic SSRI treatment during adolescence or adulthood on the outgrowth and function of the 5-HT system, using state-of-the-art Magnetic Resonance Imaging (MRI) techniques and other,…

Long-term effects of psychotropic medication on the developing brain. A cohort study based on medical prescription data

Primary objective of the study: 1. To report on the age-dependency of the effect(s) of MPH or SSRI treatment on the outgrowth of the DA and 5-HT systems, respectively, using state-of-the-art Magnetic Resonance Imaging (MRI) techniques

The efficacy of a physical intervention study for the improvement of the rest-activity rhythm and working memory in persons with Down*s syndrome suffering from Alzheimer*s disease. A pilot-study

The primary objective of the study is to examine the feasibility of measurements, program design and implementation adherence of a cardiovascular exercise program in persons with Down*s syndrome suffering from Alzheimer*s disease. Secondary…

recovery of visual field defects after stroke - a pilot implementation

The goal of the study is twofold: (1) to study whether the earlier observed positive *lab-results* (training effects) are also observed in a rehabilitation setting, using evaluation techniques that are common in such a setting. If we observe…

A strategy game supporting goal management training intervention for the treatment of executive problems after acquired brain injury: A randomized controlled pilot study for usability and preliminary efficacy

The primary objective of this pilot study is to investigate the feasibility of GMT with a new game that incorporates strategy training inimproving executive functions in a pilot sample of brain-injured patients. This study investigates the usability…

Evaluation of the Karman Line memory strategy training, a combined computerized and face-to-face compensatory treatment targeting memory complaints after acquired brain injury, using single-case experimental design methodology.

The primary objective is the evaluation of the potential positive effect of a compensatory memory strategy game on effective coping with memory problems and reducing subjective memory failures in ABI patients with memory deficits in the chronic…

Evaluation of a Compensatory Brain Game supporting Goal Management Training intervention targeting executive function after Acquired Brain Injury using single-case experimental design methodology

The primary objective of this study is to assess whether the use of a compensatory brain game supported GMT treatment could be of interest in people with EF deficits after ABI, to improve goal achievement, their executive function performance during…

Tired! Recharge and re-engage: a program to treat fatigue for youth with Acquired Brain Injury

To test the feasibility and preliminary effectiveness of the MOE! program in young people (12-19 years old) with ABI in four rehabilitation centers (Basalt/Merem/Revant/Heliomare) and update the program where needed based on experiences and outcomes…

A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Single and Multiple Doses of Donepezil with Glycopyrrolate or Trospium in Elderly Volunteers

Primary objectivesPart 1To evaluate the single dose safety and tolerability of donepezil 10 mg when administered with placebo, glycopyrrolate or trospiumPart 2To evaluate the safety and tolerability of donepezil when given with concomitant placebo,…