39 results
Objective of this study is to investigate cytokine production and expression of toll-like receptors on monocytes in blood samples from pregnant and non-pregnant women using sonicates from different types of oral pathogenic micro-organisms and…
To assess if the studied TCD variables of cerebral autoregulation and hemodynamics are abnormal during preeclampsia. And if so, to determine if these changes are large enough to have potential value to determine a threatening cerebral dysfunction in…
Determination of psychosocial effects after severe, early onset preeclampsia for improvement of care of these patients in the future.
To determine and compare the periodontal status between the different groups of women. Periodontal examinations will be performed within one week after delivery. If periodontal disease is diagnosed within the selected groups, it is plausible to…
The primary objective of this study is to determine the ability to diagnose (in a clinical validation study) the health of the early foetus by using the non-invasive nanoCAGE RNA-sequencing test using circulating cell-free RNA isolated from first…
The main objective of this study is to analyse the effect of fetal sex on levels of T and macrophage cell subsets in decidual tissue. Secondary objectives will be to analyse differences in the effect of maternal blood stimulation by fetal leukocytes…
To determine the vaginal microbiota composition during preeclampsia
The primary objective of this study is to generate reference values for NFMS parameters as well as for 2D-STE parameters during the second trimester, 16 until 28 weeks gestational age. The secondary objective is to investigate the diagnostic…
The overall aim of this study is to assess WML and associated existing and novel SVD imaging markers to dissect the pathophysiological mechanisms underlying WML in young to middle aged women at risk for future cardiovascular disease. We aim to…
The aim of the DONOR study is to define if OD pregnancies, specifically those with immunogenetic differences between mother and child, are associated with abnormal placentation and vasculogenesis, resulting in distinct maternal immunomodulation and…
- to analyze the changes in the gut microbiome of IBD patients during pregnancy and try to find an association with disease activity - to analyze whether changes in the gut microbiome remain after post partum period of 3 months-to analyze gut…
a) To evaluate whether PAPP-A2 and inhibin A could be used as biomarkers for preeclampsia and preeclampsia-related outcome in twin pregnancies. To achieve this objective, we will first assess:- Whether PAPP-A2 and inhibin A levels are increased in…
To identify differences in immune cell repertoire between pregnant women with critical COVID-19, mild COVID-19 and healthy controls.
The current study will investigate whether the FSL can be used to establish the diagnosis GDM in women who became pregnant after bariatric surgery. To accomplish this, first it will be necessary to gain insight into the continuous glucose pattern of…
In this study the primary objective is to investigate whether activation of TRPV1, TRPA1 and TRPM3 by selective channel agonists induces vasodilation in human dermal arteries. If the primary objective is achieved, the secondary objective is to…
We hypothezise that hypertension in pregnancy, spontaneous preterm birth and cardiovascular disease in later life share pathophysiological features of endothelial dysfunction. We will investigate this on two levels including local on tissue level…
Primary objective: To determine the association between serum adiponectin and the risk of developing gestational diabetes. Secondary objective: To determine the association between serum leptin in pregnancy and the risk of developing gestational…
1. To investigate whether children exposed to lithium or antipsychotics in utero have subtle structural brain differences compared to non-exposed children at the age of 8-14 years old (primary objective).2. To investigate whether children exposed to…
We aim to examine the differences in response of hemodynamic and ventilatory parameters between women in their first trimester of pregnancy and non-pregnant women during a CPET.