277 results
Our overall aim of the our project is to evaluate the long-term treatment effects of bracing and surgery in patients with adolescent idiopathic scoliosis, with a minimum 25 years follow-up. Secondly, to determine clinical and/or radiological…
The primary goal is to evaluate the difference between diaphragm tissue characteristics and movement in extubated COVID-ICU patients after >72 hours of invasive mechanical ventilation compared to other ICU-patients and healthy controls.…
The academic network of GPs *PrimEUR* in Rotterdam and the South-West of the Netherlands consists of 12 GP health centers. In addition another 14 GP practices will be recruited. All eligible children aged 6 to 12 years old in the participating GP…
Despite seeing an increase in children admitted to the paediatric intensive care unit for severe acute asthma, we still do not know what the cause of this increase is, and we still only have few drugs we can give these children, regardless of the…
Identifying the pro-inflammatory biomarker profile in the pathophysiology of acute sever lung disease in SARS-CoV-2 infection, and using this profile to identify the patients who are at risk of developing acute severe lung disease and multi-organ…
Assess BMP10 secretion in patients with pulmonary arterial hypertension and its effect on right ventricular adaptation to pressure overload.
The aim of this study is to identify why a subset of COPD patients develops such a severe COPD at early age and with relatively few packyears smoking. This will need a functional genomics approach integrating both whole genome DNA sequencing data in…
The aim of this pilot study, the *Ventilation, inflammation, perfusion and structure imaging in Neonatal Lung patients* (VINyL) study, is to develop a safe and fast MRI protocol for neonatal airway, lung and cardiac imaging in neonatal lung patients…
The final goal of this validation plan is to develop an MRI platform that can provide information about ventilation, inflammation, perfusion and structure (VIPS-MRI) in a single MRI examination of 30 minutes for safe and efficient monitoring of CFLD…
Our main aim is to develop a biomarker-based method to decide whether treatment with antibiotics is required for treatment of individual hospitalized AECOPD patients. We hypothesize that our biomarker-based intervention, using PCT levels to guide…
Objective: Identification of host biomarker signatures that have discriminatory difference in patients with a bacterial respiratory tract infection. Secondary objectives Identification of host biomarker signatures that have discriminatory difference…
Remimazolam for long-term sedation during invasive mechanical ventilation in critically ill patients
To elucidate whether a sedation regimen with remimazolam can reduce the ICU length of stay in critically ill patients with renal failure, compared to patients treated with a sedation regimen with midazolam.
The aim of this project is to unravel whether BPD after the neonatal period is a chronic inflammatory disease, and if markers of inflammation and/or oxidative stress are related to pulmonary morbidity in patients with BPD. Based on these findings,…
We aim to characterize innate anti-viral defence responses in the upper airways of COPD patients.
We aim to identify if pediatric PAH patients have increased plasma IL-1β and IL-18 compared to control participants, as well as increased caspase-1 cleavage and NLRP3, IL-1β and IL-18 mRNA expression in PBMCs, reflective of inflammasome activation.…
Determine the optimal set of implementation strategies to introduce ERATS in the Netherlands; evaluate whether high protocol adherence indeed leads to the expected reduction in length of hospital stay, complications, and readmissions, alongside…
The aim of the study is:• to determine the long-term effect of bariatric surgery on asthma symptoms, lung function, quality of life and systemic inflammation