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Effect of Coxiella burnetii infection on health status of patients following an outbreak of Q fever.

To determine the health status of the patients of the Q fever outbreak in the Netherlands in 2007, one year after primary Q fever infection.

the Application of an Electronic Nose in the Early detection of ASpergillosis

to establish the accuracy with which the eNose can discriminate patients with invasive pulmonary aspergillosis from controls

Early detection of bacterial airway infections in children with primary ciliary dyskinesia and cystic fibrosis by electronic nose

We hypothesize that expiratory VOC-analysis by electronic nose is capable of: a.) discriminating CF-/PCD-patients with and without pulmonary infections and b.) discriminating CF-/PCD-patients and healthy controls.

Sarcoidosis and Fatigue: Influence of successive cardiopulmonary exercise testing on fatigue, ACE, cytokine response and acitivity pattern

This study will investigate fatigue after exercise in sarcoidosis patients. It will determine the severity of their fatigue, the recuperative capacity after maximal exertion (bicycle ergometer) and the levels of ACE and cytokines (before and after…

Visualization of the microcirculation of the nasal mucosa in vivo in different nasal disorders, using Sidestream Dark Field (SDF) imaging

To assess the normal nasal microcirculation in vivo. Also, this research may lead to a better understanding of the pathophysological mechanisms operative in nasal dysfunction. It may help us to differentiate between aetiology of different disorders…

Effect of high-frequency chest wall oscillation and manual hyperinflation on the resolution of atelectasis in ventilated patients

Studies provide statistically significant evidence of the effectiveness of high-frequency chest wall oscillation administered via The Vest* System.St. Elisabeth Ziekenhuis Tilburg wants to demonstrate the effectiveness of HFCWO on ventilator-…

An early diagnosis of asthma in young children by using non-invasive biomarkers of oxidative stress/airway inflammation

This study can be divided in two parts:1) an early asthma diagnosis in young children2) study of etiological factors in relation to the development The main objective of this study is an early diagnosis of astma by the use of non-invasive biomarkers…

Volatile organic compounds in breath as marker of asthma and COPD: studies on methodologic aspects

Study 1.Primary Objective: To investigate whether a portable electronic nose system (Cyranose 320) can discriminate the smell-prints before and (several time points) after the smoking of 1 cigaretteSecondary Objective(s): Is the effect the same for…

Early post-trauma and post-surgery neutrophil functions in the development of ARDS

To test the hypothesis stated above, we propose to study the dose-response relationship between various chemostimulants and PMN functions of major trauma patients and patients undergoing major surgery in vitro, both early after the initial trauma or…

Breath, sputum, serum and urine analysis for the diagnosis of tuberculosis; characterisation of volatile biomarkers for TB

The aim of our study is the development of a simple device that is able to differentiate between sputum from TB patients and non TB patients.With the knowledge and concentration of the VOCs from M. tuberculosis and possible the specific host…

Which processes drive the accumulation of cytotoxic CD8+ T cells in the lungs of COPD patients?

In the present project we aim to characterize the lung CD8+ T cell immune system and analyse if differences exist between *healthy* smokers and COPD patients. If so, these data will help to clarify the (immuno)pathogenesis of COPD. Specifically, we…

The effect of nasal provocation on clinical response and nasal inflammatory parameters in nonallergic rhinitis, mixed rhinitis and allergic rhinitis patients versus healthy individuals

By a chemical, physiological and IgE-mediated nasal provocation test, nasal responses will be provoked in different patientgroups. The clinical response will be measured by visual analogue score, rhinitis symptomscore, peak nasal inspiratory…

The electronic nose in the discrimination of parent reported and doctor confirmed wheeze

We hypothesize that expiratory VOC-analysis by electronic nose is capable of:1. Discriminating between asymptomatic infants and infants with respiratory wheeze.2. Discriminating between parent-reported and doctors-confirmed wheezy infants.The aim of…

Exposure assessment to quartz in construction workers with a elevated risk to silicosis

which particles can be found in induced sputum of construction workers? What is the composition, size and concentration of quartz particles measured in sputum of the different exposure groups?

Postoperative oxygenation pattern in patients with obstructive sleep apnea - a pilot study

to study postoperative oxygenation patterns in patients with OSA during the first three postoperative nights and 6 weeks after operation. The results of these observations will be compared to other patients groups with known respiratory compromise…

Orbitrap mass spectrometry analysis of exhaled breath condensate (EBC) of asthmatic children - a pilot study

The study will be divided into two projects: Reproducibility study: To assess reproducibility of analysis of EBC by means of Orbitrap MS, in asthmatic children, with and without atopy.Correlation study: To correlate the results of Orbitrap MS…

Physical fitness of preterm children aged 6 and 7 years. The influence of daily fysical activity level and the attitude of parents on fysical fitness.

The first aim of this study is to obtain insight in the physical fitness of ex-preterms. The second aim is to study the influence of the daily activity pattern of the children on physical fitness. The third aim is to study the attitude of parents…

Exercise-induced oxidative stress and peripheral muscle dysfunction in COPD; single-leg ergometer test versus whole-body exercise test.

To investigate (1) whether basal levels of oxidative stress differs between COPD patients and healthy volunteers and (2) whether exercise-induced oxidative stress after a single-leg ergometer test differs between patients and healthy controls (3) to…

Quantitative and qualitative determination of natural occuring regulatory t cells in blood and bronchoalveolar lavage fluid of patients with pulmonary sarcoidosis and healthy volunteers.

The primary goal of this research is to characterize the regulatory Treg population in peripheral blood and bronchoalveolar lavage in patients with sarcoidosis compared to healthy controls. What is the frequency of these cells, what is the phenetype…

Diagnosing expiratory flow limitation in COPD patietns with forced oscillation technique using linear regression in the time frequency domain

The obtained FOT parameters can distinguish the group of COPD patients with expiratory flow limitation in body plethysmography from the patients without expiratory flow limitation in body plethysmography.