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Ammendment of protocol: Intravenous iron treatment in iron deficient patients with idiopathic pulmonary arterial hypertension. Title amendment: Skeletal muscle strength in healthy persons and patients with pulmonary hypertension

To evaluate the effects of intravenous iron suppletion in iron deficient PAH patients.Amendment: to compare exercise capacity and isolated muscle strength in IPAH patients and healthy controls

The role of the pulmonary vasculature in the Fontan circulation

Primary Objectives:- Determine the effect of pulmonary vasodilatation on indexed cardiac output during simulated exercise.- Characterization of structural properties of small pulmonary arteries.Secondary Objectives: - Investigate the effect of…

Non-invasive assessment of lung remodeling in patients with idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH) using [11C]-Nintedanib or [18F]-FLT PET imaging.

To investigate whether enhanced expression of growth factor receptors (FGF-R, PDGF-R and VEGF-R) and increasedvascular cell proliferation in the lung of IPF or PAH patients can be assessed using [11C]-Nintedanib or [18F]-FLTPET/CT imaging.

The pressure overloaded right ventricle: a deformation imaging study

1. To characterize and compare RV myocardial structure, contraction patterns, and functional capacity of (A) PH patients (group 1 or 4, the latter are to be inoperable), (B) patients with pressure overloaded RV due to CHD and (C) healthy controls. 2…

Exercise-induced pulmonary hypertension in fibrotic idiopathic interstitial pneumonias. Correlations with cardiopulmonary exercise testing

The primary aim of this observational study is to determine the occurrence of (exercise-induced) pulmonary hypertension (sPAP > 40 mmHg) in IIP patients with an elevated V*E/V*CO2 at AT (> 34) assessed during CPET. And, secondly to…

Imaging of Ventricular Reversed Remodeling after Double Lung Transplantation in Patients with Pulmonary Arterial Hypertension

To study remodeling patterns of the left and right ventricle in patients with pulmonary arterial hypertension who underwent lung transplantation, using cardiac magnetic resonance imaging.

It's LiFe! Innovative monitoring and personalised feedback as a self-management tool in disease management programmes for people with COPD and/or type 2 diabetes; a randomised controlled trial

The main objective of this study is to measure the effects of the monitoring and feedback tool embedded in a Self-management Support Program on physical activity. The secondary objective is to measure the effect on self-efficacy, quality of life and…

The effect of N-acetylcysteine and ascorbic acid on pulmonary arterial pressure and ventilation during normoxia, hypoxia and hyperoxia and total oxidant capacity.

In this study we will therefore investigate the influence of hypoxia and anti oxidants on HVR and HPV.

Efficacy and safety of home treatment versus in hospital treatment with LMWH in patients with non-massive pulmonary embolism

1. To evaluate the efficacy and safety of out of hospital treatment with LMWH and Vitamin K antagonists in consecutive patients with objectively proven acute non-massive pulmonary embolism2. To perform a health economics evaluation in all patients3…

Quantification of pulmonary vascular remodelling in pulmonary arterial hypertension patients using positron emission tomography

To non-invasively quantify pulmonary vascular remodeling in pulmonary arterial hypertension using [18F]-FLT (determination hyperproliferation).

Right Ventricular neurohormonal signalling in patients with Pulmonary Arterial Hypertension using Positron Emission Tomography

Therefore, the aim of our study is to determine whether and when changes in sympathetic signalling in the RV of IPAH patients occur, using [11C]-HED and [11C]-CGP-12177 PET imaging.

Long-term outcome after heparin plus edoxaban versus heparin plus vitamin K antagonists for acute deep vein thrombosis and pulmonary embolism

To assess the long-term PE-related Quality of Life and to assess the cumulative incidence of PTS in patients with acute DVT, treated with heparin plus edoxaban in comparison to patients treated with heparin plus warfarin. Furthermore, the…

The efficacy and safety of initial triple versus initial dual oral combination therapy in patients with newly diagnosed pulmonary arterial hypertension: A multi-center, double-blind, placebo-controlled, Phase 3b study

Primary objectiveTo compare the effect on pulmonary vascular resistance (PVR) of an initial triple oral regimen (macitentan, tadalafil, selexipag) versus an initial dual oral regimen (macitentan, tadalafil, placebo) in newly diagnosed, treatment-…

A multiple dosing study to demonstrate the safety, tolerability, pharmacokinetics and efficacy potential of intravenously administered ANXV (a recombinant human Annexin A5) in patients with confirmed moderate to severe COVID-19; The CO-ANNEXIN Study.

Primary Objective:To evaluate the efficacy potential, safety and tolerability of intravenously administered ANXV, in ascending doses, and two different dosing regimens, in patients with confirmed moderate to severe COVID-19.Secondary Objectives:To…

Non-invasive assessment of lung remodelling in patients with pulmonary arterial hypertension (PAH) using [18F]-FLT PET imaging.

To investigate whether increased vascular cell proliferation in the lung of PAH patients can be assessed using [18F]-FLT-PET/CT imaging.

Experimental in vitro characterization of chronic thromboembolic pulmonary hypertension.

The primary objective of this study is to investigate the role of vascular cells, with focus on pulmonary arterial endothelial cells (PAEC), in the development and pathogenesis of extensive thromboembolisms as observed in CTEPH.

*MR PulmonalIsangiografie ter veRvanging vAn CT- Pulmonalisangiografie bij patiënten met de klinische verdenking op LongEmbolie; de MIRACLE studie*

Het primaire doel is het bepalen van de sensitiviteit en specificiteit van de MR Pulmonalis Angiografie (MRPA) waarbij de CT Pulmonalis Angiografie (CTPA) de gouden standaard is.** Als secundaire uitkomsten: het bepalen wat de klinische…

A randomized trial of ultrasound-facilitated, catheter-directed, thrombolysis versus anticoagulation for acute intermediate-high risk pulmonary embolism: The higher-risk pulmonary embolism thrombolysis study

The primary objective of the study is to assess whether ultrasound-facilitated, catheter-directed, thrombolysis and anticoagulation are associated with a significant reduction in the composite outcome of PE-related mortality, cardiorespiratory…

Detection Of Latent Pulmonary Hypertension In Genetically Susceptible Individuals.

We hypothesize that the development of a follow-up program of unaffected mutation carriers will lead to early identification of disease and in the development of strategies to prevent the development of disease and successful treatment.

A randomized trial of ultrasound-facilitated, catheter-directed, thrombolysis versus anticoagulation for acute intermediate-high risk pulmonary embolism: The higher-risk embolism thrombolysis study

The primary aim of the study is to evaluate whether treatment with the EKOS device on top of anticoagulation in patients with severe pulmonary embolism results in a better clinical outcome than treatment with anticoagulation alone. The primary…