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The pathogenesis of dengue virus infection in patients with sickle cell disease

To elucidate the pathogenetic mechanism of endothelial cell activation in DENV infected patients with sickle cell disorder.

NeutrOphil acTivity and dIversity (phenotype) in Sickle Cell disEase and their changes after treatment; The NOTICE study

The overall aim of this project is to delineate the role of neutrophil activity and diversity in the pathogenesis of acute (e.g. vaso-occlusive crisis (VOC) and Acute chest syndrome (ACS)) and chronic complications in sickle cell didease and its…

Investigating red blood cell deformability of sickle cell patients who started therapy.

Investigating red blood cell deformability changes, during treatment, measured with hyperoxia-hypoxia ektacytometry in sickle cell anemia patients, patients with HbSC disease and patients with HbS-beta-thalassemia.

Immunophenotypic Profile of Peripheral Blood Mononuclear Cells and T cell Function in Sickle Cell Disease Patients.

The characterization of the immunophenotypic profile of PBMC subsets in steady state SCD patients. The determination of general T cell function in SCD patients. Both will be used as reference profiles in further research evaluating immune…

Discriminating between thalassemias and iron disorders with the Laser optical rotational cell analyser (Lorca).

Assessing different modalities of ektacytometry in diagnosing thalassemia and/or iron disorders. Investigating the influence of hemoglobinopathies and iron disorders on red cell membrane deformability in comoparison with healthy controls.