204 results
To contribute to building a sound scientific basis for the regulatory EU institution to set-up occupational exposure limits and related biological limit values, as well as reference values for the general population and to study the impact of the…
Primary Objective: The primary objective of this study is to investigate the prevalence EPI in the advanced HF population Secondary Objectives: • To determine the association between exocrine pancreatic function and markers of HF• To determine the…
Phase 1: Assess reliability of advanced respiratory muscle ultrasound imaging in healthy subjects and congenital myopathies/muscular dystrophies. Phase 2: assess two year follow-up of respiratory function using advanced respiratory muscle ultrasound…
1) Our first aim is to determine the involvement of GALT (Peyer*s patches, mesenteric lymph nodes) and peripheral lymph nodes in the immune deregulation that is observed in IBD2) Our second aim is to understand the pathophysiological mechanisms in…
The primary objectives are to: (1) Examine whether emotional incongruence (i.e., the mismatch between self-reported emotion and observed emotion from facial expression) is more common in patients with FND than non-FND control groups (healthy…
Our objective is to find predictive biomarkers for disease progression in RVCL-S, a monogenetic small vessel disease, and to dissect disease mechanism to identify new treatment targets to improve health for RVCL-S patients, which may also serve as…
PART A and PART DTo assess the safety and tolerability of TAK-994 following multiple oral doses in subjects with narcolepsy with or without cataplexy (NT1 or NT2).PART B and PART C To assess the efficacy of TAK-994 on reducing excessive daytime…
To compare the in vitro potency of commonly used antiplatelet drugs in the blood of patients with various stages of fibrosis due to MAFLD, compared to that in blood of individuals without underlying liver disease.
The primary objective of this study is to measure to what extent a 12-week grouptherapy program with horses leads to an improvement in the quality of life of military veterans that are diagnosed with PTSD. Quality of life will be measured using the…
To determine the impact of prior BCG vaccination on the duration of immunogenicity of the BioNTech/Pfizer mRNA COVID*19 vaccine.
The primary objective of this study is to establish molecular profiles in lower rectal biopsies as close to the internal fistula orifice tissue and fistula scrapings based on single cell RNA sequencing, cellular protein expression by CyTOF and…
The primary objective is to determine if there is a difference in autonomic function between patients with Alzheimer*s disease (MCI and AD) and a matched control group. The secondary objectives will be explorative and aimed to investigate…
Our primary aim is to evaluate in clinical practice the predictive value of unruptured intracranial aneurysm wall enhancement for aneurysm growth. It will allow to set up a secure, efficient and personalized follow-up.
Primary objective:Investigate if a trained immunity profile in innate immune cells might be a mechanism of HIV elite control.Secondary objectives:1. Determine the immune phenotypes that distinguishes family members of HIV elite controllers from…
In a way, the turbulence elicited by blood passing the stenotic valve can be seen as 'labeling' the ejection phase of the heart. This makes it possible to distinguish this phase from the presumed phase of arterial contraction. Systematic…
To contribute to the evaluation of 'fasting mimicking diet' application in oncotherapeutic setting and to gain insight on the underlying mechanisms in response to a fasting mimicking diet. This explorative study focuses on the immune…
To examine the thermophysiological responses to prolonged exercise in hot and humid environmental conditions in patients with a history of exertional heat stroke or malignant hyperthermia susceptibility and compare the thermophysiological responses…
Primary Objective:To evaluate the efficacy potential, safety and tolerability of intravenously administered ANXV, in ascending doses, and two different dosing regimens, in patients with confirmed moderate to severe COVID-19.Secondary Objectives:To…
This study has been transitioned to CTIS with ID 2024-514073-22-01 check the CTIS register for the current data. To investigate differences in coagulation between (Omniplasma) and FFP in paediatric cardiac patients, who are undergoing cardiac…
To asses if there is a difference in functional outcome between open reduction and fixation of the posterior fragment in trimalleolar AO-Weber B fractures with additional medium-sized posterior fragment (5-25% of the involved articular surface, AO…