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Long-Term Multi-center Evaluation of E-Poly* and Regenerex* Cementless Acetabular Components: Clinical and Radiographic Outcomes

The purposes of this long-term mutli-center study are: - To compare the long-term (10-year) radiographic and clinical outcomes of new E-Poly* liner in primary total hip arthroplasty with the conventional ArcomXL® polyethylene liner.- To compare the…

Mucoviscidosis and Inflammation, Variability through Exercise and Training: physical exercise program

Primary objective:What is the effect of a 12 weeks physical exercise program on the exercise induced inflammatory response in patients with cystic fibrosis?Secundary objectives:- What are the differences in pre-training basal immune values of…

Validation and standardization of the measurement of pelvic floor dysfunction with the MAPLE-probe

A. Determine the placement of the Maple-probe in relation to the anatomy of the pelvic floor musculature.B. Determine the normal rest tone of the pelvic floor musculatureC. Determine the normal activity of the pelvic floor musculatureD. Determine…

Scalp cooling during radiotherapy on the skull

n.v.t.

A Randomized Study of Stopping Treatment at 24 Weeks or Continuing Treatment to 48 Weeks in Treatment-Naïve Subjects with Genotype 1 Chronic Hepatitis C who Achieve an Extended Rapid Viral Response (eRVR) While Receiving Telaprevir, Peginterferon Alfa2a (Pegasys®) and Ribavirin (Copegus®)

Primary:To estimate the difference in SVR rates between T12/PR24 and T12/PR48 treatment regimens in subjects who achieve eRVR.Secondary:To evaluate the safety of telaprevir in combination with Peg-IFN-alfa-2a and RBV in treatment-naïve subjects with…

A partly blinded single center trial studying the effect of daily oral treatment with 30 mg prednisolone during two weeks on metabolic and disease activity parameters in patients with severe chronic atopic dermatitis and in healthy volunteers

Primary objectives:• To explore whether daily oral treatment with 30 mg prednisolone modulates biomarkers for adverse metabolic effects in a similar manner in patients with chronic atopic dermatitis as compared to healthy volunteers.• To determine…

Metamemory intervention in stroke patients: long-term effects on social participation and quality of life

The aim of this study is to investigate the effect of a MSE intervention on social participation and quality of life in chronic stroke patients. This MSE intervention will be compared to a controlgroup in order to measure the additional effect of…

Mindful Mirror Exposure in the Treatment of Eating Disordered Patients

Primary objective: to determine the effect of Mindful MirrorExposure in the treatment of eating disordered patients.

A classification algorithm for low back pain: matching patients to treatments that they are most likely to benefit from

To evaluate the (cost)effectiveness of a classification algorithm, based on patient*s symptoms andclinical presentation, that directs patients with non specific LBP to the therapy (exercise therapy ormanual therapy) that they are most likely to…

The long-term effect of the babysitterprocedure after proximal nerve injury.

Aim of this study was to assess the long term effects of the babysitter procedure in patients with proximal nerve injury.

Bone marrow derived mesenchymal stem cells for the treatment of allograft rejection after renal transplantation

Primary: 1 to test the safety and feasibility of autologous MSC therapy in HLA-DR mismatched patients with SCR in the renal biopsy 4 weeks after renal transplantation.Secondary1 To assess histologic changes before and after MSC treatment.2 To…

Function of the masticatory system after high partial condylectomy in patients with unilateral condylar hyperactivity
- a retrospective study on the function of the masticatory system including the temporomandibular joints after condylectomy in patients with Unilateral Condylar Hyperactivity -

To answer the next questions::What is the (long term) function of the TMJ in UCH patients after a condylectomy in comparison to a control group matched for age and gender?How do UCH patients score the function of the TMJ after a condylectomy?

Preconceptional modification of sex ratio by means of natural methods

The primary objective is to establish whether the natural preconceptional sex selection method (a diet in combination with a timing advise for intercourse), as applied by Gender Consult, is effective.

Matched treatment of obesity in overweight patients. A randomised controlled trial.
(pilot is non-randomised treatment-control study. This ABR application pertains to the pilot study)

The present project aims at giving obese patients new opportunities to loose body weight by enabling care providers to match treatments to patients by using an evidence based matching procedure with the Dutch Eating Behaviour Questionnaire (DEBQ).…

The development of a method for prediction of future glucose values using additional vital body signs.

Primary objectives: * Continuous glucose values with registration of carbohydrate intake, vital signs, physical activity, emotional stress and insulin delivery. The data will be used to develop forecasting algorithms for glucose levels on a time…

Coronary versus Intravenous abCiximab administration during Emergency Reperfusion Of ST-segment elevation myocardial infarction - the CICERO trial

To investigate whether IC administration of abciximab during primary PCI is superior to IV administration in improving myocardial perfusion in patients with STEMI.

mRNA-transfected dendritic cell vaccination in high risk uveal melanoma patients

The primary goal is to show the capability of monocyte-derived DC after RNA electroporation for melanoma antigens to induce an immune response.The secondary objective is to show clinical response.

An Open-Label, Phase I Study to Evaluate the Pharmacokinetics and Tolerance of Co-administration of Oral Multiple Dose of Ketoconazole and an IV (bolus) Infusion of Eribulin in Patients with Advanced Solid Tumors

Primary objective: To study the influence of repeated oral administration of ketoconazole, a potent CYP3A4 inhibitor, in a therapeutic dose on the plasma pharmacokinetics (PK) of eribulin administered via intravenous (IV) infusion.Secondary…

The effect of long-term olive-oil based parenteral lipid use on immune functions: a patient-control study

To evaluate immune function and (the susceptibility for) oxidative damage under the influence of long-term olive-oil based TPN use in patients without an active underlying disease and compare this with findings in healthy controls

Genetics in Efavirenz Metabolism, the GEM study

To find an explanation for the abnormal blood levels of efavirenz. With the main research question: Are variations in genetic markers, e.g. CYP2B6 (subtype *6, *7 and *18), for the metabolism of efavirenz, an explanation for the abnormal…