Search for a trial

Unmet LDL-C target in very high risk cardiovascular patients

To assess the prevalence of LDL-C >1.8 mMol/L in a subgroup of very high risk patients with ASCVD, who remain at a very high-residual risk for ACS, despite treatment with high-intensity statins in combination with ezetimibe. This subgroup of…

Exploring the impact of acellular pertussis immunisation during pregnancy on the differences in the immune response of infants after primary immunisations with an acellular pertussis containing vaccine: an open label study

Primary objective:To investigate Pertussis Toxin (PT) specific antibody responses 1 month following the second aP vaccine given at 5 months of age to infants whose mothers have (Arm 1) or have not (Arm 2) received a pertussis booster vaccine during…

The effect of AVELLE negative pressure wound therapy in reducing postoperative wound complications in patients undergoing mastectomy and flap fiXation : a validation study

To evaluate the effect of Avelle negative pressure wound therapy in reducing postoperative wound complications after mastectomy with flap fixation and closed suction drainage.

Preliminary study testing the ReCoVRY Virtual Reality-application as an adjuvant AUD therapy in the inpatient immediate post detoxification phase. A new Coaching Application based on Virtual Reality Exposure.

This preliminary quasi experimental study aims to explore the experiences of patients using a newly developed VR application as an adjuvant in the treatment of AUD after clinical detoxification in DSM-5 diagnosed AUD patients. This study aims to…

BMI dependent regulation of macrophages and monocytes in pregnancy

Primary Objective: analyse the effect of maternal BMI on levels of macrophage cell and monocyte subsets in decidual tissue and maternal blood. Secondary Objective: analyse differences in the effect of maternal blood stimulation with conditioned…

Long-term protection after primary yellow fever vaccination in elderly persons (60 years or older at the time of primary vaccination)

The results of this research contribute significantly to the field of Travel Medicine, especially for elderly travelers who have been vaccinated with YF-17D at 60 years or older, and who are planning to visit a yellow fever endemic country in the…

The effect of prolonged and repeated moderate-intensity exercise on inflammation in patients with Inflammatory Bowel Disease.

The primary objective is to investigate the effect of prolonged and repeated moderate intensity exercise on faecal calprotectin in patients with IBD. Secondary objectives will be to investigate the effect on inflammatory markers and clinical disease…

Effects of the National Diabetes Challenge with or without a self-management app for personalized lifestyle advice, self-monitoring and behavior change in people with type 2 diabetes

Primary Objective: to compare the effects of two interventions on lifestyle behaviour (food intake and physical activity) and quality of life in people with T2DM. The interventions include the National Diabetes Challenge (*NDC-only group*), and a…

Investigation of maternal HEmodynamics and right ventricular function in PRegnant women with Tetralogy Of Fallot

To investigate maternal hemodynamics, with particular focus on right ventricular function in relation to uteroplacental flow characteristics in pregnant women with ToF.

Electromechanical profiling of arrhythmogenic substrates and triggers in the long-QT syndrome

To identify arrhythmogenic electromechanical risk profiles in LQTS patients; in baseline conditions and during provocation; the recognition of risk profiles will improve risk stratification for sudden cardiac death.

Single-handed, double loaded: The effect of an increase in biomechanical loads and central sensitization on the presence of musculoskeletal complaints in upper limb absence and brachial plexus injury.

The overarching aim of this project is to study the factors contributing to MSC in individuals with one functional hand. The two primary objectives are: (P1) to examine the presence of muscle fatigue, caused by imbalance between biomechanical loads…

TUbectomy with delayed oophorectomy as alternative for risk-reducing salpingo-oophorectomy in BrcA-Women to assess the Safety of Prevention: the TUBA-WISP II study

To evaluate RRS with delayed RRO as an alternative for RRSO in BRCA1/2 gene germline mutation carriers. We hypothesize that RRS with delayed RRO leads to an equal ovarian cancer incidence when compared to RRSO.

Improving cardiometabolic health through nudging dietary behaviours and promoting physical activity in adults with low socioeconomic position: implementation and evaluation of the SUPREME NUDGE trial

To evaluate the effect of environmental nudges and pricing strategies in the supermarket, as well as a mHealth (mobile health) physical activity intervention, primary on the dietary intake.

Multi-Interventional program for prevention and early Management of Anastomotic leakage
after total mesorectal excision in Rectal cancer patIents, IMARI-trial

To increase the one year anastomotic integrity rate in patients undergoing total mesorectal excision (TME) for rectal cancer by the routine and quality controlled implementation of a multi-interventional program, which includes:1. MBP with oral…