45 results
The aim of this study is to investigate the effect of guided tapering in early pregnancy as compared to continuation of SSRIs during pregnancy. We will study effects on both mother and child with a pragmatic approach.
The primary objective of this investigator initiated project is to determine whether the use of the WalkinSense in the production of new fully customized therapeutic footwear for diabetic patients with a history of foot ulceration results in lower…
To study the incidence of (mild) acute hyponatremia in ecstasy users at rave parties.
To investigate what the ideal moment to vaccinate would be, early (after 2-6 months) or late (after 9-12 months) after cessation of rituximab. Secondly to study the immune-response to vaccination with influenza virus vaccine after treatment with…
This evaluation research will focus on six elements (1) the technical evaluation of the system (2) the validity and reliability of the system, (3) the succession of the protocol, (4) the effects of the Quiet Care System for the client, the informal…
Main objectives: Establishing the effect of BF as predisposing factor for the development of VGE and hence DCS by using subjects with a restricted range in age and VO2max. Establishing the effect of TC/HDL ratio and FFA as predisposing factors for…
To investigate in situ a possible effect of 4 different tootpastes on the developement of dental erosion and on the composition of the pellicle.
This study will evaluate the effect of approximately 10 years of pravastatin treatment on IMT in young adults with FH. Furthermore, safety parameters and psychological aspects with respect to early treatment initiation will be investigated.
Study the risk of colorectal adenomas in patients detected with duodenal adenomas.
To determine the effect of probiotics (microbial food supplements) on acquisition rates and colonization prevalence of CC17 ARE in two wards where ARE-colonization is endemic.
The purpose of the study is to conduct a randomized controlled trial with the self-help intervention *Voluit leven* for adults with mild to moderate psychological distress. The research question is: What are the effects of the preventive self-help…
To investigate the maintaining factor of mood-congruent memory bias of depression, the circumstances when they occur and the neural correlates of these.
The aim of this project is to investigate whether a first trimester model of 3D placental volume, 3D power Doppler measurement of the placental vascularization and/ or serum levels of PAPP-A, PlGF, PP-13, PAI, Ang-2, sFlt and SEng can predict early…
To demonstrate attenuated ischemia-reperfusion damage in subjects that have become tolerant due to repeated endotoxin administrations.
The evaluation of a group therapy for patients with depressive symptoms after stroke - a pilot study
The objective of the study is to investigate the effect of the *Coping with depressive symptoms after stroke* course on depressive symptoms and quality of life in a waiting list controlled study.
The aims of the study are fourfold: 1) to assess dual-task walking performance in patients with late sequelae of polio and compare this to dual-task walking performance of age-matched healthy controls; 2) to investigate the reproducibility of a dual…
Objective of this study is the development of a national "best practice guideline on pre and postnatal follow up for prenatally detected abnormalities of the kidney and/or urinary tract". Furthermore, the guidelijne will be evaluated and…
Are overweight or obese patients protected against atherosclerosis when suffering from haemophilia A? Is this association influenced by the severity of haemophilia? When the coagulation activity increases due to obesity (and inflammation), will this…
Aim of this study is to investigate the effects of oral administration of GTS-21 in healthy volunteers on cytokine release in ex-vivo TLR agonists stimulated whole blood . Pharmacokinetic and pharmacodynamic data will be collected with respect to…
The goal of the study is to find out whether micturition complaints are prevented or reducted by the bladder instillations with Uracyst and secondly if it has a positive effect on painscores and micturition related quality of life.