497 results
The goal of the project is to validate the developed standardized atrophy measurement method at VU University Medical Centre in patients with MS. This is done by testing how well the measurements of atrophy agree between different scanners and…
The main objective of this study is to evaluate the differences in [18F]FEOBV binding between PD patients and healthy control subjects, in order to evaluate the clinical feasibility of [18F]FEOBV as a cholinergic imaging ligand in PD. Secondary…
DEfective HUman SAlivary gland stem cells: the cause of Primary Sjögren*s syndrome?
-DEHUSAPS study-
To assess whether salivary gland stem cell (SGCS) defects are key to salivary gland pathogenesis in pSS.
The aim of this study is to explore the added value of the indol profile in comparison to serotonin in platelets and 5-HIAA in urine for diagnosis and potentially management of neuroendocrine tumors including gastrinomas, pNETs and brochopulmonary…
The main goal of the study is to evaluate the feasibility of using 1) passive treadmill belt speed perturbations to measure spinal reflex activity in the calf muscles; and 2) active real-time visual feedback on dedicated gait parameters to highlight…
To quantify muscle relaxation properties of fingerflexors using transcranial magnetic stimulation in patients with different myopathies to develop a screening diagnostic tool to assess who does (not) suffer from an underlying myopathy.
In the current study, we want to demonstrate Rienso uptake in the vessel wall in patients with cardiovascular disease and relate the uptake of Rienso to endothelial permeability.
1). To compare temporal fluctuations of lung function and inflammatory biomarkers in blood, nasal lavage, exhaled air and urine between patients with asthma and controls.2). To investigate the change in variations of these biomarkers upon…
Is the BOLD MRI able to show the difference in the level of oxygenation as a mesurement of ischemia between a in a healthy kidney (<30% renal artery stenosis) and a kidney with more than 70% artery stenosis?
To explore and optimize the usability of Doppler-OCT scanning of conditions affecting any of the retino-choroidal layers.
The above anounced studies suggest that some abnormalities in the Wnt pathway can be expected to affect development and function of the brain, potentially leading to recognizable behavioural phenotypes. Given the key role of APC in the Wnt pathway,…
Primary Objective: to show the differences in distribution of microbial DNA proximal versus distal in the colon as well as luminal composition versus mucosa adherent. Secondary Objective: to test whether bowel lavage has influence on the microbial…
Main question: What is the lung function of late preterm births compared with children born at term at age 12? Sub-questions: - Which respiratory symptoms in late preterm infants at age 12?
The current randomized study aims to evaluate potential differences between the Edwards SAPIEN bioprosthesis and the Medtronic CoreValve® system with main focus on periprosthetic aortic regurgitation and additional focus on other clinical and…
The main objective of this study is to assess more thoroughly the differences in gait patterns between COPD patients and healthy controls. Other objectives are to assess differences in gait patterns between GOLD stages and two age groups in healthy…
Primary Objectives:A. To assess the reproducibility and variability (interscan, intra- and interreader) of novel (DCE-)MRI techniques to measure vessel wall dimensions, wall shear stress and vessel wall permeability in healthy and cardiovascular…
The main goal of this study is to validate the VR-game as a tool to provoke OCD symptoms and assess OCD symptom severity. The first objective is to investigate whether the VR-game is able to provoke OCD symptoms in OCD patients. The second objective…
Research questions: Primary questions:* Are the new point-of-care instruments for the measurement of VOCs in exhaled breath feasible for use in children and adolescents aged 6 to 20 years?* Are these techniques able to differentiate between healthy…
Compare hemodynamic parameters and flow patterns of the stented Mitroflow bioprosthesis, stentless Freedom SOLO bioprosthesis,transcatheter Edwards Sapien bioprosthesis and healthy control subjects, measured with 4D flow MRI.
The objective of the study is to investigate the applicability of the whole body MRI protocol in Gaucher disease. To do so, we will investigate:1. If whole-body MRI ironmeasurements represent the distribution and total amoount of Gauchercells in the…