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Application of cultured autologous keratinocytes in combination with a meshed split skin autograft for burn wound healing

ObjectiveEvaluation of the application of cultured autologous keratinocytes in combination with a meshed split skin autograft to improve burn wound healing

Genes and gene-function in bicuspid aortic valves

The primary objective of this study is to identify mutations associated with the development of a bicuspid aortic valve. To this end the study will focus on genes important for aortic valve formation. As an extension of the primary objective, a…

Investigating the genetic building blocks of emotion and behaviour in the general population

This study aims to identify the relationship between candidate genes such as for instance BDNF, 5-HTTLPR, DAOA, G72, DTNBP1, NRG1 and COMT with cognitive function and emotional- and behavioural traits.

Prediction of medication response in children with ADHD: EEG differences between responders and non-responders to methylphenidate.

The EEG profile in responders to methylphenidate will be differ from the EEG profile in non-responders to methylphenidate (i.e. higher total power, increased theta/beta ratio and theta/alpha ratio).

Cortical activation during voluntary contraction in spinal cord injured subjects

In humans with SCI, we propose to use functional magnetic resonance imaging (fMRI) to: 1) examine the cortical areas that are activated during voluntary contractions, and 2) evaluate how cortical activation patterns change as a muscle is fatigued.…

A Randomized, 4-Arm, Placebo-Controlled Phase 2 Trial of AMG 386 in Combination with Bevacizumab and Paclitaxel or AMG386 plus Paclitaxel as First-Line Therapy in Subjects with Her2-Negative, Metastatic or Locally Recurrent Breast Cancer.

To estimate the treatment effect as measured by progression free survival(PFS) of subjects receiving AMG 386 (at 2 doses) in combination with paclitaxel + bevacizumabrelative to paclitaxel + bevacizumab + placebo.

PENGUIN-trial: pancreatitis, endoscopic transgastric versus primary necrosectomy in patients with infected necrosis. A randomised controlled multicenter observer-blinded trial

To investigate if endoscopic transgastric necrosectomy will lead to a reduction ofthe per- and postoperative pro-inflammatory response, as compared to necrosectomy by laparotomy, in patients with infected (peri-)pancreatic necrosis.

A pilot study of immunorespons in children with Down syndrome after Respiratory Syncytial Virus (RSV) lower respiratory tract infections (LRTI)

The primary objective is whether a difference in innate and acquired immunorespons on RSV infection exists, in children with DS compared to healthy matched-controls.

Prevention of neutrophil induced extracellular matrix damage following skin exposure to solar simulating radiation (SSR)

To investigate the effect of a sunscreen, a topical antioxidant and a topical corticosteroid on erythema, infiltrating neutrophils and oxidative stress following exposure of the skin to SSR.

Mucosal saturation measurements in patients suspected for chronic gastrointestinal ischemia

Evaluation of the diagnostic value of stomach and small bowel mucosal oxygen saturation measurements in patients suspected for chronic gastrointestinal ischemia.Determination of normal mucosal oxygen saturation values in patients without chronic…

The role of diurnal cortisol rhythm in relation to personality and QoL with regard to morbidity, prognosis and mortality in patients with suspicion of breast cancer

The aim of the study will be to examine the relationship between personality, QoL and diurnal cortisol rhythm in women with a suspicion of breast cancer with regard to morbidity, prognosis and mortality.

Prestudy Optimizing Diagnosis of Community-Acquired Pneumonia

The objective of the standardized protocol is optimalizing the accuracy of the diagnosis (all-cause pneumonia, or serotype-specific pneumonia) during the 13-valent pneumococcal vaccin (13vPnC) study which will be performed in 2008. Additionaly, the…

Skin resident T cells in atopic dermatitis and psoriasis - Escape from regulation?

To determine the frequency and suppressive potential of skin resident regulatory T cells isolated from atopic dermatitis and psoriasis patients compared to healthy control subjects (the latter data will be obtained by co-workers at the Brigham and…

Sexuality and the self: studying gender-, social- and cultural differences in sexual self-concept as an explanation for unplanned pregnancies and abortion in teenagers

Aim of the research is the development and evaluation of an intervention to promote the sexual and reproductive health of adolescents who differ in cultural background. Fundamental idea is that sex education is more effective if the information is…

Analysis of risk factors in early pregnancy to predict pregnancy complications and complications in these women later in life

This study is focused on determination of risk factors associated with preeclampsia and intrauterine growth restriction, both develop in early pregnancy. These pregnancy complications are associated with cardiovascular diseases in later life. We…

Fluoroscopic and RSA evaluation of the ROCC total knee prosthesis

The primary objective is the assessment of the in vivo kinematic patterns of a mobile bearing knee prosthesis (ROCC, Biomet Europe BV, The Netherlands) over time by means of fluoroscopy and to evaluate if the polyethylene bearing is rotating.The…

Anticipation of coming events in Parkinson*s Disease and Friedreich Ataxia: is timing more disturbed than spatial prediction?

Is time prediction of a future event specifically disturbed, compared to spatial prediction, in PD and FA, when compared to age-matched control subjects? Do the 2 patient groups differ from each other?

Correlation between oxidative stress and microvascular perfusion defects in renal ischemia/reperfusion injury during kidney transplantation: an observational study.

First, to determine the extent to which oxidative stress and microcirculatory perfusion defects occur during clinical kidney transplantation. Second, to study the relationship between these events and kidney function, inflammation and renal cellular…

Collection of Normative and Glaucoma Data Using GDx VCC Scanning Laser Polarimetry

To obtain clinical data from normal individuals to establish significance limits for the GDx RNFL measurements using the ECC method and to collect GDx RNFL measurements in subjects with early, moderate and advanced glaucoma using the ECC method to…

Phase I and IIa trial for assessment of safety, immunogenicity and efficacy against sporozoite challenge of the candidate malaria vaccine PfLSA-3-rec.

To screen two different formulations of the recombinant malaria vaccine PfLSA-3-rec, one adjuvated with aluminium hydroxide and one with Montanide Isa 720, by assessing the safety and immunogenicity (phase I) profile of each formulation in humans,…