43 results
The primary objective is to evaluate possible clinical effects correlated with α3β1 and CD151 expression in human epidermal malignancies, and relate these findings to the effects of α3β1 and CD151 deficiencies in skin cancer in the mouse.…
We aim to identify biomarkers (from neuroimaging, eye tracking, EEG, cognition, biochemistry, proteomics, genomics) for stratification of ASD. Biomarkers will be crucial to aid more accurate and earlier diagnosis of ASD. They are also needed for…
The general aim of this study is to implement validated markers for CAA in asymptomatic individuals with CMBs, to investigate whether presence of CMBs signifies early CAA.
The aim of this study is to determine whether the presence and the extent of periodontitis are independently related to the presence and extent of coronary calcification.To determine if periodontal treatment has an positive effect on the…
The primary objective in this observational study is to determine microcirculatory profile in preterm and term neonates. We would like to determine how the microcirculation changes in time during the phase of adaptation and correlate inter- and…
To study the validity and usefulness of three immunological assays to improve knowledge on the course and diagnosis of sesame seed allergy in sesame seed allergic patients with proven anaphylaxis. In the first place, the CAP inhibition assay is used…
The aim of this protocol is to invite the NeuroIMAGE cohort once more for a follow-up investigation and collect phenotypical, cognitive, and MRI data. This design offers the opportunity to examine by means of longitudinal phenotypic, cognitive, and…
Primary: 1. To determine what the effect of exercise on coagulation.2. Establish the changes in bloodcell counts as a result of exercise.3. What the effect of exercise is on the platelet function.4. To test the different effects of cycling and…
Our aim is to determine a Pharmacokinetic/Pharmacodynamic (PkPd) based dosing model for nicardipine used for treatment of severe hypertension in preeclamptic patients. The model is based upon determination of maternal, fetal and neonatal plasma…
First Objective: Is the percentage of subjects that dynamic hyperinflate during activities of daily living larger in patients with mild COPD than in healthy controls?Second Objective(s): Will dynamic hyperinflation induced by activities of daily…
To examine the long-term effects of a CT- and/or RT-induced premature menopause on BMD, cardiovascular status, neurocognitive function and QoL in female HL survivors.
As only a subgroup of breast cancer patients experience long-term cognitive decline after adjuvant chemotherapy, it is critical to identify risk factors for this decline. Some risk factor like higher age, lower cognitive reserve (either defined as…
Our objective is to test the feasibility and preliminary effects of a web-based patient portal containing a survivorship care plan, online questionnaires for symptoms and HRQL with personalized feedback and a physical activity support programme that…
1. What is the somatosensory profile of DM2 patients?2. What are the similarities and differences between the somatosensory profile of pain in myotonic dystrophy type 2 and fibromyalgia patients?
This protocol involves studies that aim at:1. A better understanding of sensory perception and eating behaviour2. Validation of newly developed sensory and behavioural methods3. To determine the effect of fat, sugar and/or salt reduction on sensory…
The objective of the proposed study is the intraoperative detection of tumor tissue of peritoneal carcinomatosis of colorectal origin by using a near-infrared fluorophore, 800CW, conjugated to bevacizumab resulting in a bevacizumab-IRDye800CW…
Whole blood thrombin generation generates reliable results which are comparable to plasma thrombin generation.
Family Group Conferencing is regularly carried out in the Netherlands as a decision making procedure in youth care. Aim is to allow families to develop their own help plan, aiming to address the problems in such way that the family continues to be…
Objectives Primary: To examine the effects of regular glucose lowering treatment on inflammatory markers in type 2 Diabetes Mellitus Secondary: To identify markers/fingerprints that predict the response of a patient to glucose lowering therapy in…
The aim of this study is to evaluate the efficacy, and feasibility of the Absorb bioresorbable scaffold in infrapopliteal hemodynamically significant arterial stenoses and occlusions.