16 results
We hypothesize that verapamil reduces progression from paroxysmal to persistent AF, improves rate control, exercise tolerance and quality of life and reduces costs compared to metoprolol.
We aim to clinically establish that the subscapularis is crucial for glenohumeral stability in two work packages. In work package 1, we will test the hypotheses that at baseline patients with degenerative subscapularis tears: 1) advocate…
Objective: To compare histology, gene expression profile (using transcriptome analysis and quantitative Polymerase Chain Reaction (qPCR) validation) and the microbiome of vesicular endogenous hand eczema between and within patients and to skin of…
The primary research aim is to identify the adaptation system as a dynamical network or complex adaptive system in which the constituent parts interact and are showing critical phases via critical phase transitions from a disease phase with serious…
Primary ObjectivesParts 2To evaluate the safety and tolerability of INCB001158 for patients with advanced/metastatic and/or treatment-refractory solid tumorsParts 3To evaluate the safety and tolerability of INCB001158 in combination with…
To evaluate the effectiveness of a multidisciplinary outpatient group-based nutrition and lifestyle intervention program *Reverse diabetes type 2* executed by Voeding Leeft on self-reported haemoglobin A1c (Hb1Ac) as measure of glucose regulation…
To study the impact of primary keratinocytes isolated of allergic contact dermatitis (ACD) cases on THP-1 cell activation.
1. Induce acute stress in healthy volunteers and study whether changes occur in some of the main ECG indicators of ANS control of cardiac electrophysiology.2. Visualize and quantify the neurochemical effects in the brain (including amygdala and…
The primary goal of the current research is to determine the accuracy of the procedure using patient-specific cutting guide. Secondary endpoints are surgical time needed and the guides* fit onto the patients* tibia.
To investigate whethere there is a difference in gastric emptying (emptying half-time t50) after ingestion of cow milk between lactose tolerant, habitual milk consumers reporting no gastro-intestinal symptoms and non-habitual milk consumers…
In this project we will establish primary keratinocyte cell lines of patient skin biopsies from selected skin diseases, to generate 3D skin constructs. In addition, patient DNA will be genotyped for genetic risk factors (psoriasis and AD) or…
To study whether stable renal transplant patients show higher protein oxidation measured with the 13C-breath test as compared to healthy kidney donor subjects.
1.3. Study Design Rationale The ATLAS-PPX trial (ALN-AT3SC-009) is a multicenter, multinational, open-label Phase 3 switching study designed to demonstrate the efficacy and safety of fitusiran in patients with hemophilia A or B, with inhibitory…
Primary ObjectivesThe main purpose of this study is to compare how long subjects with oesophageal cancer live overall (called overall survival, OS) or live without disease progression (called progression free survival, PFS) after receiving BMS-…
The main objective of this study is to compare Hem-Col® as a method to draw blood and measure the parameters used in the routine follow-up laboratory checks after bariatric surgery to the present standard method at the laboratory at the MC…
The objective of this study is to evaluate blood pressure response after renal denervation in patients with uncontrolled hypertension compared to a sham-controlled population, in the absence of antihypertensive medications. In this study, *…