189 results
To assess the prevalence of LDL-C >1.8 mMol/L in a subgroup of very high risk patients with ASCVD, who remain at a very high-residual risk for ACS, despite treatment with high-intensity statins in combination with ezetimibe. This subgroup of…
To determine the content validity and clinical utility of the Dutch sPCI according to nurses with expertise in stroke care and stroke patients, respectively.
The aims of this study are (1) to determine if ear absorbance can be used to non-invasively measure ICP and (2) to determine if ICP differs between glaucoma patients and controls.
There is evidence however that abdominal wall blocks, such as TAP blocks, could help managing the postoperative pain, but covering the visceral pain is not possible with this technique. It is not even clear to date which component of pain, the…
This study investigates the impact of a goal directed nutritional support protocol on sarcopenia in oncological patients undergoing an esophagectomy and secondary the incidence of anastomotic leakage and pneumonia, surgical infection and lenght of…
Primary: to determine if inhibition with GPB can provide a significant (>30%) reduction in the accumulation of orally administered Iodine-123 in salivary glands, measured at 4h after administraion. Secondary: to determine if a reduction at 4h…
To determine whether DUX4 can be detected in epithelial or stem cells isolated from midstream urine and/or buccal brush biopsies and/or skin punch biopsies of FSHD patients. Hereby we will assess whether any of these biomaterials can be used as an…
To assess the presence of absence of ILCs in preclinical (early) pSS biopsies as well as to assess their potential interaction with epithelial cells.
We aim to prevent or reverse developmental regression in patients with Kleefstra syndrome. We hypothesise that the regression we observed is the result of a psychotic disorder, which isnot properly recognised by clinicians and often not treated…
The primary aim is to assess myocardial development and function of the left ventricle in fetuses with the suspicion of aortic coarctation on fetal echocardiography. The secondary aim is to study left ventricular blood flow movement with vector…
Therefore the objective of this study is to test the feasibility of the detection of circulating tumor DNA of a variety of tumors in peripheral blood using a novel detection process.
Describe the electrocardiographic changes and areas of late myocardial activation encountered in PLN and PKP2 mutation carriers during ajmaline provocation and the relation of these differences to the development for early stages of arrhythmogenic…
1) Assess whether individuals with ASD perform pantomimes with similar kinematics to typical individuals, and whether the typicality of their kinematics can be explained by motor impairment.2) Assess whether individuals with ASD are able to utilize…
The main study objective will be to determine whether a newly developed rehabilitation protocol is non-inferior to the current rehabilitation protocol - golden standard - used after ACL reconstruction.
To ascertain the amount of UV-damage (p53 activation, apoptosis, thymidine dimers and γH2AX) is caused by the Dermasun treatment in psoriasis patients.Total skin check in patients using Dermasun for a prolonged period of time to screen for (pre-)…
The aim of the project is to validate biomarkers for the development of a peripheral blood test which can distinguish early inflammation between various forms of IBD, with the use of novel techniques, such as mass cytometry and RNAseq.
Objective: to investigate calcium containing crystal release in synovial fluid after exercise as drivers of synovitis in post-traumatic versus non-post traumatic osteoarthritis.
The primary objective of this study is to measure the effectiveness of the TFT for URMs living in the Netherlands. The research question is as follows: is this TFT effective in decreasing symptoms of posttraumatic stress and depression in URMs…
The primary objective of the study is to examine muscle atrophy in fetuses with single or bilateral IPEV, in comparison to a normal population by measuring the circumference of the upper and lower legs by ultrasound examination. The length of the…
1. Explore the diagnostic value by comparing muscle volume, fatty infiltration and oedema/inflammation using qMRI in MG patients, healthy controls and MG mimics (other neuromuscular diseases and Graves* ophthalmopathy (GO) patients).2. Explore the…