149 results
The objective of this study is to deep phenotype CIndU (subtype SD and ColdU) and detect novel biomarkers for diagnosis and treatment response as well as establish methodologies for (non-) invasive monitoring of treatment effects in chronic…
To estimate the feasibility and safety of early weaning from ICU treatment in patients after cardiac arrest and an early (< 12 h) favourable EEG pattern.
The primary endpoint is the accuracy of urine production monitoring using the automated Flowsure monitor compared to the standard manual method of monitoring.
This study has been transitioned to CTIS with ID 2024-518965-85-00 check the CTIS register for the current data. The primary objective of this study is to investigate the potential differential effects of RTX and OBI on the composition of lymph…
Primary Objective: - To assess the effect of MMR-0 vaccination on the humoral immunity against measles 2 years (+/- 2 months) after MMR-2 vaccination.Secondary Objective(s): - Determine the effect of MMR-0 vaccination on the humoral immunity against…
The study aims to isolate and culture mesoangioblasts from muscle biopsies of two patient groups suffering from skeletal muscle atrophy to assess their potential for autologous muscle stem cell therapy. To relate this potential to the underlying…
The first aim is to determine an objective acoustic measure to define SMS by comparing acoustic features of probe words to a perceptual score of speech motor movement characteristics and stuttering frequency judged by the expert (i.e., the current…
Primary:- Investigate the feasibility of examining fetal and neonatal brain developmental trajectories in the fetus and neonate with at least one parent with SMI in the mood-psychosis spectrum (vs. parents without SMI) using MRI.- Acquire…
Primary objective: Compare characteristics of endothelium from older individuals with or without previous unprovoked VTE.Secondary objectives: 1) Determine the blood plasma proteome between the different groups and 2) to evaluate the prothrombotic…
The objective of this study is to evaluate the (nationwide and international) implementation of ICG-fluorescence for SN-procedures for patients with breast cancer.
1. To identify immunological alterations in peripheral lymphoid/skin/synovial tissue of patients with psoriatic artritis and psoriasis2. To correlate these alterations with disease stage, prognosis, treatment response3. To compare immunological…
Primary Objective: To study alterations in microcirculatory oxygenation during exercise in patients with long-COVID in relation to clinical symptoms. Secondary Objectives: To study in patients with long-COVID compared to convalescent controls•…
The primary objective of this trial is to assess the efficacy of immediate CAS among patients with acute ischemic stroke treated with EVT and a severe ipsilateral proximal carotid artery stenosis (>50%) or occlusion and compare this with the…
Primary Objective:Our primary objective is to generate in-depth immune profiles, which include phenotypic and functional analyses, as well as epigenetic and transcriptomic analyses, of several B cell, T cell, and monocyte subsets, which relate to…
The aim of this longitudinal study is to find new biological, clinical and/or electrophysiological biomarkers in order to define and differentiate individual diagnoses of NT1 and the NBL, and to find improved treatment targets and strategies.
To determine whether a standardized exercise workload elicits a different response on 1) metabolites/cardiac biomarkers in the general circulation (measured by blood values), and 2) contraction patterns in local myocardium (measured by…
Hoofddoel: We aim to assess the utility of ultrasound-defined contractile performance as a biomarker for monitoring disease progression and treatment effects in patients with FSHD.Stage I:Primary Objective:To establish the feasibility, optimal…
This study has been transitioned to CTIS with ID 2023-510481-27-00 check the CTIS register for the current data. This study evaluates the yield of NIR-Fluorescence imaging as additional surgical-tool for visualization and assessment of local extent…
Objective: The main objective is to evaluate the monocyte phenotype of children with FH compared to normocholesterolemic controls and to explore the effect of statin treatment.
The primary objective of the registry is:To analyse coronary artery disease progression with or without coronary artery bypass grafting.The secondary objective of the registry is:To report graft patency following bypass grafting of diffusely…