2506 results
The purpose of the study is to investigate the effect of (repeated) cast immobilization on the bone strength of the lower leg in patients with diabetes mellitus. In this study, bone strength is examined by cortex thickness in millimeters and density…
To determine the prevalence of mycobacterial, propionibacterial and beryllium, aluminium and zirconium sensitized patients within a well-defined Dutch cohort of biopsy proven sarcoidosis patients.New clinico-pathological phenotypes within the group…
The main objective of this study is to determine the role of freeze-fight-flight reactions in the development and maintenance of PTSD symptomatology.
The aim is to critically evaluate the additive effect of EMDR to ERP on treatment acceptability, drop-out, and outcome; a) does EMDR lead to a decrease in OCD related memory representations (or in other words; does it lead to a decrease in the…
Our primary objectives are to study in patients with OCD 1.) Whether stress facilitates a shift from goal-directed to habitual behaviour (both appetitive and avoidant); 2.) Whether stress facilitates compulsive behavior through an enhancement of…
Primary objectivePhase 1: To assess the safety and tolerability of Nab-paclitaxel added to oxaliplatin and capecitabine at their currently optimal doses.Phase 2: To determine the anti-tumor activity of Nab-paclitaxel when co-administered with…
The main objective of the proposed study is to investigate whether the disproportionally strong clinical effects of fingolimod in RRMS can be explained by enhanced functional brain adaptation and whether enhanced functional adaptation is sustained…
In this study we aim to investigate the presence of CAN in diabetic patients scheduled for elective major abdominal and thoracic surgery and its relation with perioperative hemodynamic changes.
The main objective is to identify the source of the *musician effect*, particularly for speech perception. The underlying processes involved and individual differences in different groups of participants in speech and music perception, both in quiet…
Primary Objective: To assess which measures of microvascular function on 7T MRI are affected in patients with CADASIL, relative to controls.
To assess swallowing and speech function in patients ten years after CRT for head and neck cancer with preventive rehabilitation in order to compare these results with those after six years and to those of patients after CRT without preventive…
The main objective of this pilot study is the application of a home-based exercise strategy that helps patients to return faster to their functional level of before the surgery. At first, practical feasibilty of the exercise strategy delivered by…
The primary objective for this study is to evaluate the cerebrovascular reactivity of HCHWA-D patients:1. To compare the (autoregulatory) function of small brain vessels in HCHWA-D patients with matched controls using the cerebrovascular reactivity…
The aims of this project are to:1. Assess what percentage of breast cancer patients experience accelerated gain in fat mass, loss of muscle mass and muscle strength as induced during chemotherapy2. Assess whether changes in energy intake, protein…
Primary ObjectiveTo assess in 20 adolescents with anorexia nervosa the cognitive flexibility in response to two computerised category learning tasks and compare these results to a age and gender matched control group. Task one will present pictures…
The main objective of this study is to obtain more insight in the (human) mechanism underlying BVR by assessing the correlation between response of BVR to preload variation in study subjects (with and) without electrical remodelling (based on…
Objective: We want to extend our understanding of the disease aetiology by performing a small pilot study that incorporates other immunologic sites involved in the disease (the skin and the microbiome) while additionally strengthening our disease…
Primary Objectives The main objective of this project is to evaluate the long-term disease burden in meningioma patients. More specifically, we will evaluate: 1) the level of cognitive functioning and HRQoL in meningioma patients at least 5 years…
To investigate whether a clinical medication review, focused on the perceived hindering complaints and personal wishes of the patients regarding their medication, improves health-related quality of life of older persons aged 70 years or older using…
The aim of our study is to measure 1) the prevalence of signs of child abuse and neglect in children with functional defecation disorders, 2) whether signs of child abuse and neglect are more common in children with functional defecation disorders…