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Multiple Sclerosis Family Study - Study to investigate whether rare gene mutations cause Multiple Sclerosis (MS) in ten Dutch families with multiple MS patients

Our primary objective is to identify de novo/rare mutations causative of MS using WES in members of multi-incident families. Our secondary objective is to describe phenotypes per family using questionnaires and semi-structured interviews with family…

The frontotemporal syndrome in amyotrophic lateral sclerosis: screen, impact, imaging and pathology.

The main objectives are: 1. to develop a diagnostic tool for the assessment of the frontotemporal syndrome. 2. To investigate the structural and functional brain networks of ALS patients with and without a frontotemporal syndrome, in order to gain…

Brain network analysis in preterm infants using electro-encephalography

We hypothesize that functional brain network measures may serve as a marker for (disrupted) neurodevelopment in very preterm born infants. Objective: we propose to perform two studies aiming to answer the following questions.Phase 1: Retrospective…

Pericardial Tissue and the Post Pericardiotomy Syndrome

1. To get new insights in the pathophysiology of PPS by comparing tissue characteristics (histology) of the pericardium in patients with and without PPS. 2. To identify biomarkers that are associated with PPS by collecting 4 blood- and 1 pericardial…

Quantitative Sensory Testing in Failed Back Surgery Syndrome and Complex Regional Pain Syndrome Patients during Dorsal Root Ganglion stimulation

The primary objective of this study is to investigate attenuation of pain and sensory thresholds during dorsal root ganglion stimulation using QST. The secondary objectives of this study are to investigate 1) To assess changes in pain intensity (NRS…

Reorganisation of the Motor Cortex After Transhumeral Arm Amputation.

The aim of the study is to assess the cortical reorganisation after arm amputation using functional connectivity between and within the left and right motor hand areas using resting-state fMRI, and structural connectity using diffusion tensor…

The effect of periodontitis on innate immune activation and vascular wall inflammation in relation with atherosclerosis

The main objective of this study is to investigate whether a long lasting pro-inflammatory phenotype, the characteristic of trained immunity, is present in circulating monocytes of patients with severe periodontal disease and whether this correlates…

Gait analysis of servicemen after combat foot injuries during operation Task Force Uruzgan.

To assess functional outcome and using gait analysis to quantify kinematic and kinetic abnormalities of servicemen who suffered foot injuries due to combat actions.

Calibration of non-invasive measurement of mitochondrial oxygenation in healthy volunteers

Calibration of the mitochondrial oxygen tension technique in the human skin

Intestinal production of Imidazole Propionate in healthy and obese subjects with or without DM2;
a pilot trial

To study the pharmacokinetics of non-reactive labelled histidine (L-HISTIDINE:HCL:H2O (D5, 98%; 15N3,98%) and the effect on intestinal imidazole propionate (IP)production in small intestine vs colon in healthy controls, metabolic syndrome and DM2…

The Lipid-Rich Plaque Study

The Lipid-rich Plaque Study will be performed in patients undergoing IVUS-NIRS imaging (the index procedure) in whom a TVC catheter will be purchased and used for routine clinical indications. The study will test the ability of multi-vessel NIRS…

Objective home-based bradykinesia assessment in Parkinson*s disease - a pilot study

This project aims to determine the validity of a home-based continuous bradykinesia assessment using free typing behaviour analysis. Secondarily, we aim to capture the presence of sequence effect in Parkinson's Disease patients using a computer…

Observational multi-center, prospective study to develop a novel multi-parametric diagnostic model for hospitalized patients and patients on the Emergency Department presenting with lower respiratory tract infections and/ or sepsis.

To develop a novel multi-parametric diagnostic model for the management of patients with LRTI and/or sepsis that will be based on novel pathogen- and host-related factors.

Prevention of intimal injury during transradial coronary intervention

To prevent vessel damage of the radial artery by using the Cordis Railway sheathless guiding catheter system.

The PEPaNIC long-term outcome study: Neurocognitive developmental deficit
after critical illness in children: role of modifiable epigenetic changes

We hypothesise that, in comparison with the current practice of aggressive nutritional support, tolerating caloric deficits early during critical illness in critically ill children has *carry-over* effects, through epigenetic changes, that improve…

Cortical Plasticity in Type II Diabetes Mellitus

Aims of the Study: Our main aim is to characterize cortical brain plasticity in individuals with impaired fasting glucose (IFG) and patients with type II diabetes mellitus (DM2) as compared with age-, gender-, and IQ-matched healthy controls(HC).•…

Influence of exogenous growth hormone administration on circulating levels of Klotho in paediatric patients with isolated growth hormone deficiency.

To assess the impact of treatment with rhGH on circulating Klotho levels in paediatric patients with IGHD.

Implementing Self management using eHealth for monitoring and management after Catheter ablation in the treatment of Atrial fibrillatioN.
A study on the diagnostic accuracy and the effects of eHealth rhythm monitoring on patient related outcomes, clinical management and health outcomes.

Optimise post PVI management using ambulant continuous patient-driven eHealth monitoring after catheter ablation in the treatment of atrial fibrillation.Primary Objective:1) Determine the effect of eHealth on clinical management, outcomes and…

Long-term efficacy and safety of microwave ablation in the treatment of mild axillary hidradenitis suppurativa: a randomized intra-patient controlled trial

Primary objective: To prospectively evaluate the lesion (AN-)count, i.e. abscesses, inflammatory nodules, and draining sinuses, in the axilla treated with MWA compared to the untreated contralateral axilla after six months.Secondary objectives: - To…

The association between Sleep bruxism and Temporomandibular disorder Pain

1. How does muscle overloading expressed by pain effect SB characteristics?2. What SB characteristics are associated with jaw-muscle pain?3. Are SB and psychological stress contributing factors for TMD pain?