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Bandolera trial: The 'Banded' Gastric Bypass

To research in three groups whether there is a significant difference between RYGB and BRYGB patients.

Minitub: Prospective registry of Sentinel Node (SN) positive melanoma patients with minimal SN tumor burden who undergo Completion Lymph Node Dissection (CLND) or Nodal Observation

With this prospective registry we aim to evaluate the outcome of patients with a T2-T3 primary melanoma and minimal SN tumor burden, treated by CLND or nodal observation:* The main objective is to determine if T2-T3 melanoma patients with minimal SN…

The effect of oral ingestion of casein protein versus whey protein on plasma amino acids, satiety and anorexigenic hormones after gastric bypass surgery

To investigate whether a test meal in gastric bypass patients with supplemented casein protein results in higher concentrations of satiety-related plasma amino acids and satiety-related hormones and leads to more postprandial satiety and less hunger…

Transfusion of fresh frozen plasma in non bleeding ICU patients

With the aim to restrict inappropriate FFP transfusions to critically ill patients, a randomized clinical trial will be conducted in a subgoup of ICU patients undergoing an invasive procedure. The objective is to assess the effectiveness and costs…

A prospective single-blinded randomized multi-center clinical trial comparing the clinical efficacy and patient acceptability of open selective haemorrhoidopexy with stapled haemorrhoidopexy

The purpose of this prospective randomised trial is 1) to compare short- and long-term efficacy of open selective haemorrhoidopexy with stapled haemorrhoidopexy; 2) to compare patients satisfaction between open and stapled haemorrhoidopexy.

An Open-Label, Multicenter, Randomized Phase Ib/II Study of Eribulin Mesylate Administered in Combination with Gemcitabine Plus Cisplatin Versus Gemcitabine Plus Cisplatin Alone as First-Line Therapy for Locally Advanced or Metastatic Bladder Cancer

Objectives:Primary* Phase Ib: to determine the maximum tolerated dose (MTD) recommended for Phase II of eribulin mesylate (eribulin), administered in combination with gemcitabine plus cisplatin in patients with locally advanced or metastatic bladder…

Surgical technique for continuous ambulant peritoneal dialysis catheter insertion: Laparoscopic or open catheter insertion?

Primary Objective: Does the use of the laparoscopic insertion technique lower the incidence of malfunctioning CAPD-catheters at 6 weeks postoperatively? Secondary Objectives: Does the use of the laparoscopic insertion technique improve catheter…

Street Fitness In surgical patieNts undergoing general anesthesia after reversal of neuromuscular rest blockade with sugammadeX (SFINX study).

The main aim of the present study is i)To assess whether sugammadex has a positive effect on the post-operative alertness of the patients, and ii) to assess the nature, magnitude and the time of onset of this effect (if any).

Ankle treatment after injuries of the ankle ligaments

Objective of the ANKLE TRIAL is to differentiate between results of three types of functional treatment in a profound methodological way, with primary research question: what will be the optimal functional treatment for acute lateral ankle ligament…

Catheter ablation versus Amiodarone to pRevent Future ventricular tachycardia Episodes in patients with a defibrillator and a history of a myocardial infarction

Time to recurrence of sustained VT and/or appropriate ICD therapy; ATP or shock

Bard® PolySoft* pre peritoneal mesh versus Parietene* ProGrip* self-fixing semi-resorbable mesh and chronic inguinal pain development.

Objective of the Trial:Does the use of a Bard® Polysoft* preperitoneal mesh result in less chronic pain than after the use of a ProGrip*self-fixing semi-resorbable mesh for patients with an inguinal hernia repair through an anterior approach?

THE EFFECT OF MESH TYPE (ULTRAPRO VERSUS PROLENE) ON POSTOPERATIVE PAIN AND WELL-BEING FOLLOWING TOTALLY EXTRAPERITONEAL (TEP) LAPAROSCOPIC HERNIA REPAIR: A RANDOMIZED CONTROLLED TRIAL.

In this trial the outcomes of an Ultrapro mesh after endoscopic hernia repair (TEP) will be compared with the outcomes of a heavyweight mesh (Prolene) after TEP hernia repair. The primary objective is to determine the effect of a lightweight mesh (…

Effect of low-dose esketamine on postoperative delirium in patients undergoing noncardiac surgery.

Primary Objective:In this pilot study, the authors aim is to investigate whether esketamine reduces the incidence of POD in elderly patientspresenting for noncardiac surgery.Secondary Objective(s):To examine whether esketamine has an effect on the…

Anesthesia for day-case arthroscopic knee surgery in adult patients

In this study, we want to find the anesthetic technique with the highest patient satisfaction, best surgical and anesthesiological conditions and the technique with the highest time efficiency. We compare three anesthetic techniques.

Prospective randomised pilotstudy physiotherapy for patients with a subacromial-impingementsyndrome

To get an impression concerning the patient flow, degree of patient drop-out, required time for the research workers, financial costs, logistical problems and the effectiveness of treatment with tape.

A randomised controlled trial, comparing Surgical Decompression with an Interspinous Implant in patients with Intermittent Neurogenic Claudication caused by Lumbar Stenosis.

Primary objective is to demonstrate that the effectiveness of thesurgical intervention with Coflex is equivalent to surgical decompression without fusion after 1 year after surgery.Secundary objectives are to demonstrate that surgical intervention…

A randomised blinded comparison of surgical intervention with the X STOPPK® interspinous process decompression versus surgical decompression for patients with intermittent neurogenic claudication caused by lumbar stenosis

Primary objective is to demonstrate that the effectiveness of thesurgical intervention with X STOPPK is equivalent to surgical decompression without fusion after 1 year after surgery.Secundary objectives are to demonstrate that surgical intervention…

Finding best practice: use of s-ketamine peropertively and in patient controlled analgesia in the treatment of pain after major abdominal surgery

1.To compare the morphine sparing effect of low-dose ketamine in peroperative infusion and in post operative PCA (Morphine use)2.To compare the occurence of side effects.3.To compare the analgesic potential of the two therapies (VAS Scores)4.To…

Perioperative urinary output and course of diuresis during outpatient treatment under general anesthesia.

Main question:Does a restrictive fluid management during general anesthesia lead to less urinary production?Sub questions:Does a fluid management with colloid fluid during general anesthesia lead to a change in urinary production?Does a different…

Postoperative cognitive function in young adults

The main objective of this study is to identify the incidence of POCD in adult patients under 50 years of age, who undergo major surgery