243 results
To evaluate the effects of withholding progesterone-induced endometrial withdrawal bleeding before ovulation induction on the time to pregnancy and the ongoing pregnancy rate.
The primary objective of the study is:To evaluate efficacy of two doses of ESN364 versus placebo when administered for 12 weeks to decrease total testosterone (TT) levelsThe Secondary objectives are:To evaluate effect of two doses of ESN364 versus…
The aim of this study is to determine whether male microchimerism is present in patients with MRKH syndrome. This would be a sign of intrauterine cell trafficking - and possible AMH transfer- from male to female co-twin. This placental blood…
Primary: To assess the change in sexual function from baseline to 1 year in sexually active men with at least moderate BPH who are treated with Combodart, compared to placebo. Secondary: changes in sexual function during 1st 9 months of the study,…
To evaluate whether in an IVF program routine application of an ORT and a subsequent individualised FSH regimen is cost-effective compared to a standard dose regimen.
To provide clinical management and, if required, treatment to subjects who at their concluding HPV-015 study visit displayed normal cervical cytology but tested positive for oncogenic HPV infection or who were pregnant at their concluding visit of…
The objective of this study is to assess the efficacy and safety of radium-223 dichloride in subjects with human epidermal growth factor receptor 2 negative (HER2 negative), hormone receptor positive breast cancer with bone metastases treated with…
The aim of this study is to compare a reduced follow-up schedule of 4 visits among low-risk, early-stage endometrial cancer survivors, with the schedule according to the current Dutch guideline that includes 10 to 13 visits, on:Primary outcomes:1.…
To gain further insight into the interaction and possibly shared pathophysiological mechanisms of female-specific cardiovascular risk factors and events we will quantify white matter hyperintensities on brain MRI and assess endothelial function in…
To evaluate the effect of uterine bathing in improving the results of IVF/ICSI treatment in patients with endometriosis ASRM stage I-IV.
OBJECTIVE AND HYPOTHESISPrimary ObjectiveThe primary objective is to determine whether abiraterone acetate in combination with low-doseprednisone and androgen deprivation therapy (ADT) is superior to ADT alone in improving rPFS and OS insubjects…
The primary objective of the study is to gain insight in the short term and long term effects of the EFCT-ODA therapy on 1) dyadic coping abilities in the relationship and 2) relational satisfaction. Moreover, the process aspects of the ODA will be…
Investigate whether the "Smarter Pregnant" intervention in comparison with four screenings with food- and lifestyle advising leads to an improvement in unhealthy food habits (vegetables, fruit, folic acid use) after 24 weeks intervention,…
The overall objective of this study is to examine specific cardio-metabolic and cardiovascular parameters in women of subfertile couples. This study protocol is divided in 3 studies to evaluate several cardio-metabolic/cardiovascular parameters in…
The overall goal of this study is to further validate and improve the sentinel node procedure for prostate cancer using ICG-99mTc-nanocolloid. The first objective aims at further validation of the sentinel node procedure for prostate cancer via…
The objective of this study is to assess efficacy and safety of radium 223 dichloride in combination with exemestane and everolimus in subjects with human epidermal growth factor receptor 2 (HER2) negative, hormone receptor positive breast cancer…
Am2: Primary Objective* To compare the Overall Survival (OS) benefit of docetaxel and prednisone with and without lenalidomide as first-line combination therapy in chemo-naïve metastatic CRPC Secondary Objectives* Progression-Free Survival (PFS), *…
Primary Objectives* To explore the pharmacodynamic effects of topically applied omiganan in patients with external genital warts* To explore clinical efficacy of omiganan compared to placebo in patients with external genital warts.Secondary…
PrimarySafety and tolerability of MVT-602 following single dose subcutaneous administration in healthy premenopausal womenSecondaryPharmacokinetics (PK) and pharmacodynamics (PD) of MVT-602 following single dose subcutaneous administration
To study the in vitro development of embryos in a pH that better resembles the pH of the uterus.